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(11)    Patent No :    AP 2047    (73) Applicant(s)       
(21)    Application No :    AP/P/2005/003289    MERIAL LIMITED, 3239 Statellite Boulevard, Georgia,       
            Duluth, Georgia 30096,       
(22)    Filing Date :    29.09.2003    United States of America       
(24)    Date of Grant &    18.09.2009           
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    SOLL Mark D., United States of America   
    US            60/415,627        02.10.2002    BOECKH Albert, United States of America   
    US            10/618,975        14.07.2003       
                            DE BODE Ronus, The Netherlands   
                                et al       
                                (74) Representative   
(84)    Designated State                   
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    HONEY & BLANCKENBERG   
    SD    SZ    T Z    UG    ZM    ZW               
(51)    International    Classification    A01N 43/90 (2006.01)    A61K 9/00 (2006.01)   
                            A61K 31/475 (2006.01)       
(54)    Title

Nodulisporic acid derivative spot-on formulations for combating parasites.

(57)    Abstract

This invention provides for, inter alia, spot-on compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise:

(1) at least one nodulisporic acid derivative; (2) an acceptable liquid carrier vehicle; and (3) optionally, a crystallization inhibitor. The invention also provides for a method of treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprise topically applying

to said mammal or bird an effective amount of a composition according to the present invention. Further, this invention relates to an amidation process to

prepare amide derivatives of nodulisporic acid and to intermediate formed in this process.

(56)    Documents Cited :    WO 96 29073 A    WO 98 12196 A


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