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(11)    Patent No :    AP 2037   
(21)    Application No :    AP/P/2006/003828   
(22)    Filing Date :    24.05.2005   
(24)    Date of Grant &    03.09.2009   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    04102402.7    28.05.2004

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

JANSSEN PHARMACEUTICA N.V., Turnhoutseweg 30, 2340


(72) Inventors

ANDRIES Koenraad Jozef Lodewijk Marcel, Belgium

VAN GESTEL Jozef Frans Elisabetha, Belgium

(74) Representative


(51)    International  Classification   A61K 31/47 (2006.01)

(54)    Title

Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

(57)    Abstract

The present invention relates to the use of a substituted quinoline derivative for; the preparation of a medicament for the treatment of an infection with a drug resistant Mycobacterium strain wherein the substituted quinoline derivative is a compound according to Formula (la) or Formula (Ib)

the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the, N-oxide forms thereof. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically

effective amount of the above compounds and one or more other

(56)    Documents Cited :    WO 04/011436 A


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