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(11)    Patent No :    AP 2009    (73) Applicant(s)       
(21)    Application No :    AP/P/1999/001688    GLAXO GROUP LIMITED, 980 Great West Road, Brentford,       
            Middlesex TW8 9GS,       
                   
(22)    Filing Date :    14.05.1998    United Kingdom       
(24)    Date of Grant &    26.06.2009           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    BRODIE Alastair Couper, United Kingdom   
    GB    9709945.1    17.05.1997    JONES Martin Francis, United Kingdom   
                   
                SLATER John Frederick, United Kingdom   
                et al       
                (74) Representative   
(84)    Designated State           
                   
    GM  GH   KE    LS   MW  SL    SD   SZ   UG    GALLOWAY & COMPANY   
    ZW                   
(51)    International    Classification    C07D 473/16 (2006.01)    A61K 31/535 (2006.01)   
            A61K 31/52 (2006.01)       


(54)    Title

Carbocylic nucleoside hemisulfate and its use in treating viral infections.

(57)    Abstract

There is described the hemisulfate salt of (1S,4R) -cis-4

[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene -1-methanol or a solvate thereof. Also described are preparative routes and starting compounds for making the hemisulfate salt. The hemisulfate salt is useful in medicine, particularly in the treatment of viral infections.

(56)    Documents Cited :    WO 97 49410 A   EP 0 434 450 A   WO 96 06844 A

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