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(11)    Patent No :    AP 2008    (73) Applicant(s)       
(21)    Application No :    AP/P/2005/003424    GLENMARK PHARMACEUTICALS S.A., Swisscom Building,       
            Maladiere, 23, Neuchatel, CH-2000,       
(22)    Filing Date :    11.02.2004    Switzerland       
(24)    Date of Grant &    29.06.2009           
(45)    Publication :

(30)    Priority Data                    (72) Inventors   
    (33) Country    (31) Number    (32) Date    GOPALAN Balasubramanian, India   
    IN            363/MUM/2003    11.04.2003    GHARAT Laxmikant Atmaram, India   
    US            60/519,967        13.11.2003       
                            LAKDAWALA Aftab Dawoodbhai, India   
                                et al       
                                (74) Representative   
(84)    Designated State                   
    BW    GM    GH    KE    LS    MW    MZ   NA   SL    HONEY & BLANCKENBERG   
    SD    SZ    T Z    UG    ZM    ZW               
(51)    International    Classification    A61K 31/4427 (2006.01)    A61P 29/00 (2006.01)   
                            C07D307/91 (2006.01)       

(54)    Title

Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders; process for their preparation and pharmaceutical compositions containing them.

(57)    Abstract

The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts,

their appropriate N-oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1), their analogs, their taut omers, their enantiomers, their diasteromers, their regioisomers, their stereoisomers, their polymorphs, their pharmaceutical!y acceptable salts, their appropriate N-oxide, their pharmaceutical]y acceptable solvates and the pharmaceutical compositions

(56)    Documents Cited :    US 4 222 944 A   GB 1 285 398 A   WO 02/060867 A


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