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(11)    Patent No :    AP 2005   
(21)    Application No :    AP/P/2003/002733   
(22)    Filing Date :    09.07.2001   
(24)    Date of Grant &    10.06.2009   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/216,995    07.07.2000
ZA    2000/3437    10.07.2000
ZA    2000/4924    15.09.2000

et al

(84)    Designated State

KE    LS   MW  MZ   SZ   TZ   UG   ZW
 

(73) Applicant(s)

MEDICAL RESEARCH COUNCIL, Francie van Zijl Drive, Parow Valley, 7500 Cape Town,
United Kingdom

UNIVERSITY OF CAPE TOWN, Observatory, 7500 Cape Town,

South Africa
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, CB
(72) Inventors
4100, Bynum Hall,  Chapel Hill, North Carolina
WILLIAMSONUnitedStatesCarolyn,ofAmericaSouth Africa
JOHNSTON Robert Edward, United States Of

America

KARIM Salim Abdool, South Africa

et al

(74) Representative

FISHER CORMACK & BOTHA
 

(51)    International  Classification   C07K 14/16 (2006.01)


(54)    Title

Process for the selection of HIV-1 subtype C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof.

(57)    Abstract

The invention provides a process for the selection of HIV-1 subtype (clade) C isolates, selected HIV -1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce

proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. The process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus se quence for at least part of at least one HIV gene by identifying the 10 most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV -1 subtype C isolates, designated Du422, Du151 and Du179 (assigned Accession Numbers 01032114, 00072724


(56)    Documents Cited : DE BAAR M.P. et al; AIDS RES. and Human Retrovir., vol 16. No.5.   TSCHERNING C. et al;

HIV-1, Virology vol. 241, 1998, pp181-8

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