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(11)    Patent No :    AP 1979    (73) Applicant(s)       
(21)    Application No :    AP/P/2005/003277    LUPIN LIMITED, 159, C.S.T. Road, Kalina, Santacruz       
            (East), Mumbai, Maharashtra, 400 098,       
                   
(22)    Filing Date :    20.09.2002    India       
(24)    Date of Grant &    20.03.2009           
                   
(45)    Publication :

(30)    Priority Data            (72) Inventors   
    (33) Country    (31) Number    (32) Date    ARORA Sudershan Kumar, India   
                SINHA Neelima, India   
                JAIN Sanjay, India   
                et al       
                (74) Representative   
(84)    Designated State           
                   
    GM  GH   KE    LS   MW  MZ    SL   SD   SZ    COGHLAN, WELSH & GUEST   
    T Z   UG   ZM   ZW        ZIMBABWE       
                   
(51)    International    Classification    C07D 207/335 (2006.01)    A61P 31/06 (2006.01)   
            C07D 401/04 (2006.01)       

(54)    Title

Pyrrole derivatives as antimycobacterial compounds

(57)    Abstract

Novel pyrrole derivatives of formula (I), and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacteriurn tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).

(56)    Documents Cited :    DE 19 38 904 A   BIAVA M. et al; biooorganic & Medicinal Chemistry Letters, Oxford, GB, Vol.

9, No. 20, 18 October 1999, pp2983-8    US 2 986 564 A

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