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(11)    Patent No :    AP 1977    (73) Applicant(s)       
(21)    Application No :    AP/P/2004/003142    NORBROOK LABORATORIES LIMITED, Station Works,       
            Newry, County Down, BT35 6JP, Northern Ireland,       
                   
(22)    Filing Date :    12.02.2003    United Kingdom       
(24)    Date of Grant &    19.03.2009           
                   
(45)    Publication :

(30)    Priority Data            (72) Inventors   
    (33) Country    (31) Number    (32) Date    BLAKELY William, United Kingdom   
    GB    0204712.4    28.02.2002    CROMIE Lillian, United Kingdom   
                   
                DUFFY DR Sean, Ireland   
                et al       
                (74) Representative   
(84)    Designated State           
                   
    GM  GH   KE    LS   MW  MZ    SL   SD   SZ    KAPLAN & STRATTON ADVOCATES   
    T Z   UG   ZM   ZW               
(51)    International    Classification    A61K 9/00 (2006.01)    A61K 31/167 (2006.01)   
            A61K 31/277 (2006.01)       

(54)    Title

Long acting parasiticidal composition

(57)    Abstract

A composition prepared for treating animals suffering from parasites which parasites are known to be susceptible to at least one of the avermectins. milbemycins or salicylanides, comprises for example ivermectin in an amount of from 0.1 to 10 %(w/v), a solvent selected from the group consisting of glycerol formal, propylene glycol, polyethylene glycol and combinations thereof, and a salicylanilide such as closantel in a required dosage amount for the animal to be treated, typically about 2.5mg/kg live weight of the animal to

be treated, a polymeric species selected from the group consisting of polyvinlpyrrolidone and polyoxypropylene/polyoxyethylene block copolymers, the said polymeric species improving the bioavailability of closantel to the extend that blood plasma levels of the said compound greater than 20 ppm

(56)    Documents Cited :    WO 02 09764 A    US 4 128 632 A    WO 95 05812 A    WO 95 16447 A

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