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(11)    Patent No :    AP 1972   
(21)    Application No :    AP/P/2005/003255   
(22)    Filing Date :    22.09.2003   
(24)    Date of Grant &    12.03.2009   
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
FR    02/11765    24.09.2002
(84)    Designated State

GM    GH    KE    LS   MW  MZ   SL   SD   SZ
T Z    UG    ZM    ZW
(73) Applicant(s)

LES LABORATOIRES SERVIER, 12, Place de la Defense, F-92415 Courbevoie Cedex,

(72) Inventors

VAYSSE-LUDOT Lucile, France

LECOUVE Jean-Pierre, France

LANGLOIS Pascal, France

et al

(74) Representative


(51)  International  Classification   A61K 31/34 (2006.01)    C07D493/04 (2006.01)
C07D519/00 (2006.01)   

(54)    Title

New process for the industrial synthesis of tetraesters of

5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.

(57)    Abstract

The invention relates to method for the industrial synthesis of compounds having formula (I), wherein R and R', which may be identical or different, each represent a linear or branched alkyl group (C1 -C6). The invention is intended for the synthesis of the divalent salts of ranelic acid and, more specifically, of strontium ranelate and the hydrates thereof.

(56)  Documents Cited :    EP 0 415 850 A


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