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(11)    Patent No :    AP 1968   
(21)    Application No :    AP/P/2000/001852   
(22)    Filing Date :    22.12.1998   
(24)    Date of Grant &    11.03.2009   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/068,472    22.12.1997

(84)    Designated State

GM    GH    KE   LS   MW  MZ   SL   SD   SZ
T Z    UG    ZW
 

(73) Applicant(s)

UNIVERSITY OF TENNESSEE RESEARCH CORPORATION., Suite 403, 1534 White Avenue, Knoxville, Tennessee 37996- 1527,

United States of America

(72) Inventors

WHITT Michael, United States of America

ROBINSON Clinton S, United States of America

(74)    Representative

B. W. KAHARI LEGAL PRACTITIONERS ZIMBABWE
 

(51)  International  Classification   C12N 15/86 (2006.01)    C12N 15/40 (2006.01)
C12N 7/01 (2006.01)    C07K 14/00 (2006.01)
C12N 15/62 (2006.01)    A61K 48/00 (2006.01)

(54)    Title

Recombinant rhabdovirus containing a heterologous fusion protein.

(57)    Abstract

This invention relates to a composition comprising a recombinant or genetically engineered Rhalxlovirus that expresses a Fusion Protein, such as the F protein of the Paramyxovirus SV5 strain. This recombinant Rhabclovirus may express other non-Rhabdovirus attachment proteins and/or an enhancer protein. The invention also relates to methods of making recombinant Rhabdoviruses which express an F Protein. These, recombinant compositions can be used for purposes of research, as well as for diagnostic and therapeutic compositions for treatment of diseases,


(56)    Documents Cited :    Mebatsion et al; CELL, vol . 90    Schnell M.J. et al; CELL, vol 90    Schnell, M.J. et al;

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA

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