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(11)    Patent No :    AP 1963   
(21)    Application No :    AP/P/2005/003459   
(22)    Filing Date :    28.05.2004   
(24)    Date of Grant &    03.03.2009   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    10/449,418    30.05.2003

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 
(73) Applicant(s)

RANBAXY LABORATORIES LIMITED, Plot No. 90,

Sector-32, Gurgaon-122001, Haryana,
India

(72) Inventors

SALMAN Mohammad, United States of America

SATTIGERI Jitendra, India

KUMAR Yatendra, India

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   C07D 207/00 (2006.01)    A61K 31/40 (2006.01)
A61K 31/366 (2006.01)   

(54)    Title

Substituted pyrrole derivatives and their use as HMG-co inhibitors.

(57)    Abstract

The present invention relates to substituted pyrrole derivatives of formula I, which can be used as 3-hydroxy-3-methylgluuiryl-coenxyme A (HMG -CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as we ll as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms. Its pharmaceutically acceptable salts, pharmaceutically acceptable sol-vales, prodrugs, metabolites, poiymorphs, tautomers, racemates, pure enantiomers, diastereoisomers or N-oxides wherein Formula (II).


(56)    Documents Cited :    EP 0 680 963 A   EP 0 247 633 A   US 5 273 995 A

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