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(21) Application Number: KElP/ 2009/000996       
       
(22) Filing Date: 03/06/2008       
       
(30) Priority data: 202007008068.9  08/06/2007    DE and 202007012637.9  08/09/2007    DE

(86)  PCT data PCT/EP08/0044 I 2    03/06/2008 W02008/I 485 I 8    I 1/12/2008

(73)0wner: BAYER SCHERING PHARMA  AKTIENGESELLSCHAFT ofMilllerstrasse 178, 13353 Berlin, Germany

(72) Inventor: WEBER, Wilfried of Am Stilcklesberg 10,  72296 Schopfloch,Germany

(74) Agent/address for correspondence: MURJU MUNGAI & COMPANY ADVOCATES, P. 0. BOX 75362, Nairobi, Kenya                   

(54) Title:  INJECTION DEVICE

(57) Abstract:  Disclosed is an injection device comprising parts, the relative movement of which causes the active substance to be injected. For this purpose, a receptable (103, 203), into and in which a carpule/syringe can be inserted and mounted, is retained in a housing (101, 201), the receptable (103, 203) can be moved by means of a carriage (108, 208), and a plunger (104,204) that applies a force to the pistols (II lA, I liB; 211) of the carpule/syringe is movably retained in the receptacle (103, 203). A traction rope (114, 214) which is deflected by means of a roll (I 09, 209) mounted on the carriage (1 08, 208) is provided for performing the pricking stroke, injection stroke, and retracting stroke. One end of the traction rope (I 14, 214) is connected to the receptacle (103, 204) while the other end thereof is connected to a tension spring (110, 210) that is retained on the housing (101, 201). Automatically and/or manually actuatab1e mechanisms between the housing (101, 201), the receptacle (103, 203), the plunger (104, 204), and the carriage (108, 208) control the reciprocal coupling thereof to the traction rope (114, 214) and thus the sequence of the pricking stroke, injection stroke, and retracting stroke and are fitted with at least one means that allows the user to adjust the progress profile of at least one of the strokes.

Injection Device


Technical Background

5    For the treatment of a multitude of illnesses, which are now widespread, such as diabetes; patientS   
       
    must inject themselves independently with the needed amount of an active substance/medicament,   
    using a hypodermic syringe or a carpule. To make this safer and easier, a multitude of injection   

10    devices are known that incorporate a largely automatic sequence of insertion of the needle, injection of the active substance and withdrawal of the needle.

Prior Art
15

For the use of disposable hypodermic syringes, a number of devices for automatic injection of the active substance that is contained in the syringe are known; document WO 20071033638, for
2 o instance, which forms the prior art, discloses an injection device which, while simple to operate, permits a fully automatic sequence of the above-descn'bed processes, using a two-chamber ampoule whereby a sequence of mixing, needle-insertion and injection is made possible.

25
Disclosure of the Invention

It is the object of the invention to improve an injection device in such a way that the handling 3 0 comfort and safety for the patient is improved, while providing for a simple mechanical design.

The inventive injection device meets this object with the characteristics of claim L

lt is the underlying idea of the invention that the previously seamless progression of the strokes wJ a fixed stroke duration in each case is now no longer predefined, but the user is instead enabled to
5    individually design the duration of the stroke (and, hence, the speed of the respective associated   
           
    process, such as e.g. the injection), as well as the transition of individual strokes (llnd thereby in   
    particular pauses in the sequence of the movements.)   
lO    Preferred embodiments relate. to the design of the component parts for adjusting the retention time   
       
    and injection duration.   
l5    Brief Description of the Drawings   
           
    Two preferred exemplary embodiments of the injection device will now be explained with the aid o   
    drawings, in which   
20    Figure lA    shows a side view of a first exemplary embodiment of the injection device with the   
           
        housing cover removed,   
    Figure lB    shows a section through the injection device of Figure I in its starting position in itS   
25        center plane,   
           
    Figure2A    shows a sid~ view of the injection device in the process of carrying out the mixing   
        stroke,   
30    Figure2B    shows a sectional view corresponding to Figure 2A,   
           
    Figure3A    shows a side view of the injection device during the puncture stroke;   
    Figure 3B    shows a sectional view according to Figure 3A,   
35    Figure4A    shows a side view of the injection device during the injection stroke;   
           
    Figure4B    shows a sectional view corresponding to Figure 4A,   

Figure SA    shows a side view of a fust exemplary e_mbodiment of the injection device during   
    the idle stroke,   
Figure5B    shows a sectional view corresponding to Figure SA,   
5       
Figure6A    shows a side vi~w of:a _first exemplary embodiment of the injection device during   
    withdrawal of the needle, and   
Figure6B    shows a sectional view corresponding to Figure 6A,   
lO       
Figure7A    shows a side view of the ftrst exemplary embodiment of the injection device after   
    completed withdrawal of the needle,   
Figure7B    shows a sectional view corresponding to Figure 7A,   
15       
Figure SA    shows a side view of a ftrst exemplary embodiment of the injection device during   
    resetting of the mechanics (maximum retention time),   
Figure 8B    shows a sectional view corresponding to Figure SA,   
20       
Figure 9A    shows a side view of a first exemplary embodiment of the injection device during   
    resetting of the mechanics (minimum retention time),   
Figure 9B    shows a sectional view corresponding to Figure 9A,   
25       
Figure lOA    shows a side view of a second exemplary embodiment of the injection device with   
    the housing cover removed,   
Figure lOB    shows a section through the injection device of Figure l in its starting position in its   
30    center plane •1,   
       
Figure 11 A ••   shows a side view of a second exemplary embodiment of the injection device during   
    •the punctUre stroke,   
35    shows asectional view corresponding to Figure llA,   

Figure 12A    shows a side view of a second exemplary embodiment of the injection device durin~

the injection stroke,

5    Figure 128 shows a sectional view corresponding to Figure 12A,

Figure 1. 3A • .. shows a side view of a second exemplary embodiment of the injec~on device during the idle stroke,
 

10    Figure 138

Figure 14A


15    Figure 14B Figure lSA

20    Figure lSB Figure 16A
 
shows a sectional view corresponding to Figure IJA,

.shows a side view of the second exemplary embodiment of the injection device during withdrawal of the needle,

shows a sectional view corresponding to Figure 14A,

shows a side view of the second exemplary embodiment of the injection device after completed withdrawal of the needle,

shows a sectional view corresponding to Figure lSA,

shows a side view of the second exemplary embodiment of the injection device during resetting of the maximum retention time mechanics,
 
25    Figure 168 shows a sectional view corresponding to Figure 16A,

Figure 17A shows a side view of the second exemplary embodiment of the injection device during resetting of the minimum retention time mechanics,

3 0    Figure 178    shows a sectional view corresponding to Figure 17A,   
           
    Figure lBA    shows a side view of a first exemplary embodiment of a planetary gear with a   
        rotation damping element,.   
35    Figure 188    shows a sectional view corresponding to Figure 18A,   
           
    Figure lBC    shows a sectional view of the planetary gear without planetary carrier   

shows a perspective view corresponding to Figure 18A with blocked planetary carrier,

shows a perspective view corresponding to Figure 18C without planetary carrier,
 

Figure JSF    show.s a view ,corresponding to Figure .180 with blocked planetary carrier,   
Figure 19A    shows a side view of a second exemplary embodiment of a planetary gear with two   
10    rotation damping elements,   
       
Figure 19B    .. shows a side view and a perspective view according to Figure 19A with a locked   
    . fiJ'St blocking disk,   
Figure 19C.. shows a side view and a perspective view corresponding to Figure 19B with a   
15       
    locked second blocking disk,   
Figure 19D    shows a perspective view corresponding to Figure 19B with ~lockinl!   
    disk,   
20       
Figure 19E    a perspective view corresponding to Figure 19D witho~I~;~Ifnjffi~;:cond •.   
    blocking disk,   
Figure 19F    shows a section in the plane B-B of Figure 19A,   
25    shows a first section in the plane A-A of Figure 19A, and   
Figure 190       
Figure 19H    shO\vs a second section in the plane A-A of Figure 19A.   


30
Description of the Exemplary Embodiment

To inject the active substance, a two-chamber ampoule Ill is used.  An ampoule of this t)ipe (Figure

1B) has two pistons IliA, 1 liB, resulting in two initially independent chambers Ill C, lllD.  Into
35

the first, inner chamber Ill C, which faces the cannula •112, powdered Betaferon, for example, is filled, and into the second, outer chamber lllD, a NaCl solution is filled.

If a ram 104 is now pressed against the outer piston 1118, the inner piston IliA is initially displaced as well, as the NaCI solution hydraulically transfers the force of the ram onto the inner
5    piston lilA.  As soon as the inner piston IliA has passed an overflow channel Ill E in the form of

a groove~ like convexity in the outer wall of the ampoule Ill, it comes to a standstili and the NaCl solution flows through this overflow channel 111 E into the inner chamber 111 C and mixes with the
1 o Betaferon. After the mixing process, the injection then takes place (after the puncture stroke) due to ihe continued movement of the ram 104.

Figure lA shows a top view, Figure lB shows a sectional view in the starting position of the

15
injection device.

All the components are situated inside a housing 10 I composed of two tub-shaped half-shells.  The

movable components are held inside the injection device so as to be displaceable parallel to the
20

longitudinal axis of the needle.  The components are assigned to each other as follows:

A two-chamber ampoule Ill is held in a receptacle 103.  A ram 104, to the rearward end of which a

25    control lever 105 is hinged, is held on a locking hook 102A of a spring-actuated first push-button I 02. The receptacle 103 is held on a locking hook I I 6A of a spring-actuated second push-button

116.

30

Acting on the receptacle 103 is the end of a traction cable 114 that is deflected via a roller I 09 mounted in a carriage 108 and connected to a tension spring 110 fixed to the housing 101. The
tension spring II 0 accordingly exerts a pulling force on the receptacle 103 in a direction away frorii

35

the injection site. The receptacle 103 cannot slide in an axial direction, however, because it is held by the locking hook 116A on the second push-button 116.

The deflection of the traction cable 114 via the roller 109 creates a force on the carriage 108 toward

Ill
the injection site. The carriage I 08 remains ifits position, however, because it rests against the ram

I04 via a driving feature 118, which is mounted in the caniage I 08 so as to be displaceable
5

perpendicular relative to the injection device and which is actuated by a driving spring 119, and the ram I 04 is held by the locking hook 102A on the first push-button I 02.

10    Assigned to the control lever I 05 is a first adjusting slider 107, in which a second adjusting slider• I 06 is displaceably supported. The adjusting slider I 06 provides for the uncoupling of the carriage
108 from the ram.•l04.  The adjusting sliders 106, 107 are designed as displaceably supported limit•

15    stop elements for adjustment of the needle-insertion depth and injection volume, as will be explained further below.

A pull-back handle 117, .which is connected to a pull rod 115, serves to create this starting position.

20
The pull rod liS is actuated by a pull-back spring lfO.

When the fust push-button I 02 is actuated, this causes the locking hook I 02A to move out of

25    engagement, the ram 104 is released and moves toward the puncture site until the front edge of the control lever lOS comes to rest against the _receptacle 103. This causes the outer piston I liB of the

ampoule Ill to be activated, it moves forward and canies out a mix.ing stroke HO.  This mixing

30    stroke serves for mixing of the NaCI solution with the Betaferon, as described above (Figure 2A, Figure 28). A window in the housing 10 I makes it possible to monitor the miltin#fThf~Jaafefli\,

with the NaCI solution.

35    Since the free end of the control lever I 05, on the other hand, slides on the second adjusting slider I 07 and rests on it, it cannot yield in a downward direction by pivoting at this location; the pulling
force of the tension spring II 0 toward the puncture site is therefore transferred from the carriage 108 via the ram I 04 to the receptacle 103. The receptacle 103 remains in its position, however, because it is locked in place by the locking hook 116A of the push-button 116.
5

When the second push-button 116 is now actuated, this causes the locking hook 116A to move out of engagement and the receptacle I 03 is released; this causes the ram I 04 and the receptacle 103 to

jointly move toward the puncture site under the action of the tenSion spring 110. The needle is' inserted (Figure 3A, 3B), the injection stroke HI is carried out (Figure 4A, 4B.)

Once the desired insertion depth is reached, the control lever 105 is able to pivot downward (arrow

15    in Figure 4A), since it is no longer prevented from doing so by the first adjusting slider 107 because of its recessed upper surface. Consequently, force is no longer transferred from the ram 104 to the

receptacle 103, the receptacle 103 remains in its position and only the ram I 04 continues to move

2 o toward the injection site, i.e. injection of the medication takes place, the injecti~~\lf' carried out.



Once the driving feature 11 8 that is displaceably mounted in the carriage 108 ~~~hes the ramp

106A of the second adjusting slider 106 (Figure 48), the driving.feature 118 is pUl~-Et~}V:ar.dJilld,..; the carriage 108 is thus uncoupled from the ram I 04, i.e. at this point in time the injection is

complete (Figure SB).

30

In Figure 5, a toothed rack 140, which is mounted by means of a first adjusting screw 130 in the

housing between a front and rear end position so as to be able to be freely displaced by the user, is

shown in its frontal end position, in which the retention.time is set to the maximum (maximum
35

duration of the idle stroke HX).
 
    Once the injection is complete, the toothed rack 140 strikes the second adjusting slider 106; the   
    carriage I 08 continues to move jointly with a damping element ISO that is connected to the carriage   
5    I 08, relative to the toothed rack 140, toward the puncture site, thereby causing the :idle stroke HX to   
       
    occur, during which the needle remains in the puncture site.  The relative movement between the•   
    toothed rack 140 and the damping element 150 during the idle stroke HX causes the damping   

10    element 150 to become operative. Once the carriage 108 strikes the second adjusting slider 106, the idle stroke HX is complete.

If the toothed rack 140 is not in its frontal end position it strikes the second adjusting slider 106 at a

15
later point in time and the duration for which the damping element 150 is effective is accordingly

shorter as well, as is the retention time (duration of the idle stroke HX).

If the retention time is set to the minimum value, the toothed rack 140 strikes the carriage 108 only
20

after completion of the idle stroke HX and is not displaced relative to the carriage 108 and damping element 150; the damping element 150 bas no effect and therefore does not influence the retention
time.
25

The carriage- 108 now rests ag_aipst the second adjusti.rig slider 106. Since the second adjusting slider 106 is bel.d fonn-fittingly on the housing t01 via the first adjusting slider 107, the pulling

3 o force of the tension spring 110 (which is fixed to the housing 101) now acts via the roller 109 on the receptacle 103, causing the same to be pulled back and consequently causing the needle' to be pulled• out of the puncture site (Figure 6A, 6B), the retraction stroke H3 is carried out. •
 
By folding down the pull-back handle 117, which is connected to the pull rod II 5, and by pulling• out the pull rod 115, the carriage I 08 and all other elements are pulled back into their starting
s    position (Figure SA, 8B).

During tbe process of pulling back the carriage/damping element into the starting position, the toothed rack 140 strikes the frontal first limit-stop surface 130A of the adjusting screw 130. While
10

the carriage 108 with the damping element ISO continue to move away from the punctUre site the • toothed rack 140 is held in position by the adjusting screw 130, i.e. the toothed rack 1'40 moves, . relativeto the carriage 108/damping element ISO, into the selected starting position.
15

The position of the surface 130A can be changed by means of the adjusting screw; !llld thereby the. distance by which the toothed rack 140 is displaced relative to the carriage 108/darnping element
 

20
 

ISO.
 

Figure 8A/8B shows the adjusting screw 130 in the position that produces the maximum retention

time.  Figure 9A/9B shows the adjusting screw in the position that pr'Ptrooes;t~t~mlifiJJ!ifre.mllt,ion

'•
2 5    time.  Between these two positions the retention time may be adjustl:(4tp):)ntinuo~Jy.

Once the mechanism has been moved back into the starting position, ~':.awu!e can now be, ..

removed.

30

The injection volume and needle insertion depth can be adjusted as follows:

The first adjusting slider I 07 is mounted in the housing 10 I so as to be axially displaceable, in the

35
present example with 2 locking positions ( l 0 and 12 mm, set to 10 mm in the example). These locking positions are assigned to the puncture stroke HI, since the axial position of the adjusting
 

lever I 07 detennines the distance traveled until the control lever I 05 uncouples the ram 104 from the receptacle I 03 (Figure 2A).

5    Mounted inside the first adjusting slider I 07 in a manner so as to also be axially displaceable is the second adjusting slider, in the present example with 4locking positions (1.0; 0.75; tB; 0.25; in the

example set to 1.0 mm).  These locking positions are assigned to the injection stroke H2, sin~e the

.. 1 o axiat position of the adjusting slider I 06 determines tlu~ distance traveled until thcnam l04ls uncoupled from the carriage I 08 (Figures 5A,5B) and withdmwal of the needle takes place.

If a needle insertion depth of 12 mm, for example, is now to be set, the first adjusting slider I 07

15
must be displaced by 2 mm toward the puncture site, relative to the depicted state, to the new locking position on the housing 101. Since the second adjusting slider I 06 is interlocked in position 1.0 with the first adjusting slider 107, the same now also moves by 2 mm toward the puncture site,
20
i.e. setting a different needle insertion depth has no• impact on the injection volume setting. Likewise, adjusting the injection volume bas no impact on the needle insertion depth; the settings of the puncture stroke HI and injection stroke H2 are independent from each other.
25

The second exemplary embodiment shown in Figures 10-17 proceeds from an injection device as

described in the. first exemplary embodiment, however, not for use wi~~J!0?1Jt~

hypode1111ic syringe, i.e. 3 mixing stroke does not take place.  The b#~ toncept of this exemplary
30

embodiment is that the injection• duration and/or retention time can b'll;:~t'by the patit!trU

The design and interaction of the components explained in connection with ~t~~nlm~•

3 5 embodiment ate identical in their functions, so that only the additional components will be described below based on their functions:
 
Setting the duration ofthe injection stroke:

Upon actuation of the first push button 202, the locking hook 202A moves out of engagement and

s    the receptacle 203 is released; this causes the ram 204 and the receptacle 203 to jointly move toward the pWlCture site .under the action of the ten's ion spring 210. The needle is inserted (Figute 11 A ;ifid
J l B), the puncture stroke-is earried out.

10
Upon completion of the puncture stroke a locking mechanism 221, which is subjected via a slotted hole inside a guide means 222 to a force acting in the direction of the receptacle (triggered by a

spring 223), is able to pivot into the recess in the receptacle 203.  This locking mechanism is

15
supported in the first adjusting slider 207 and is therefore independent from the selected needle insertion depth. The receptacle 203 is fixed in the inserted position via the locking mechanism 22 I.

Once the desired insertion depth is reached, the control lever 205 is able to pivot downward (arrow
20

in Figure 12A), since it is no longer prevented from doing so by the first adjusting slider 207

because of its recessed upper surface.

25    Consequently, force is no longer transferred to the ram 204.

Figure llA shows the state of the injection device at the maxirnllll(ljfiiettion duration setting, Le<a

toothed ~ck 241 makes contact simultaneously with the end of th\'{f}f,\cture ~~~&Vfl-11 limit sto'd\

30

2068 of the second adjusting slider 206.  •

If the injection duration. is settG a smaller value, the toothed rack 241 strikes the ~A at a••

3 5    later point in time.
 
    After the ram 204 is uncoupled from the receptacle 203; the receptacle 203 remains in its position   
    and the ram 204 continues to move toward the puncture site.  Starting from the point in time at   
5    which the toothed rack 241 strikes the limit stop 206B of the second adjusting slider 206, the same   
       
    remains stationary relative to the ram 204 and to a damping element 251 and the injection stroke is   
    accordingly slowed by the damping element 251.  The injection duration is therefore dependent   
1 0    upon the distance along which the damping element 251 is .effective, and this distance is adjustable   
    by the patient by means of an adjusting screw 231.  Injection of the medication takeS place, the   
    injection stroke is carried out.   
15    2.   
    Once the driving feature 218 that is displaceably supported in the carriage )'08 reaches the ramp   
    '2..   
    206A of the adjusting slider 206 (Figure 12b), the driving feature )'I 8 is pulled downward and the   
    carriage 208 is accordingly uncoupled from the ram 204, i.e. at this point in time the injection is   
20    complete (Figure 13b).   
       
    Setting the retention time:   
2 5    In Figure 13B the toothed rack 240 is shown in its frontmost position, i.e. the~ption tiDje)s set   
    for the maxi~. Once the injection is complete the toothed rack 240 strikes ~~~ond adjustirig"Z   
    slider 206. the carriage 208 continues to jointly move with the damping element 25~~~!?Jlt~.-   
3 o    toothed rack 240 toward the insertion site.  The relative movement between the toothed rack 2401iiiO   
    damping element 250 during the idle stroke HX causes the damping element 250 lo take 'effect~   
    Once the carriage 208 strikes the second adjusting slider 206, the idle stroke HX is complete.   

If the toothed rack 240 is not in its frontmost position (shorter retention time) it strikes the second adjusting slider 206 at a later point in time and the distance along which the damping element 250 is
5    effective is accordingly smaller, and so is the retention time.

If the retention time is set to the minimum value, the toothed rack 240 strikes the carriage 208 only after completion of the idle stroke HX and is not displaced relative to the carriage 208 and damping
10
element 250, the damping element 250 has no effect and does not influence the retention time.

At the end of the idle stroke, the incline of the carriage 208 strikes a ramp 222A of a guide means

15    222 and releases the locking mechanism between the receptacle 203 and adjusting slider 206 (Figure 14A).

The carriage 208 now rests against the second adjusting slider 206.  Since the second adjusting

slider 206 is held form-fittingly on the housing 201 via the frrst adjusting slider 207, the tension spring 210 (which is fixed to the housing 201) now acts via the roller 209 on the receptacle 203, causing the same to be pulled back and thus pulls the needle out of the puncture site (Figure 15A,l5B), the retraction stroke H3 is carried out.
 

By folding down.the pull-back handle 217 that is connected to the pull rod 215, and pulling out the

pull rod 215, the carriage 208 and all other elements are pulle4 back into the starting position
30

(Figures HiA, 16B).

During the process of pulling b~tck the carriage 208/damping_element 250 and ram 204/damping

3 5 element 251 into the starting position, the toothed rack 240 strikes the surface 230A of the adjusting screw 230, and the toothed rack 251 strikes the surface 231A of the adjusting screw 231. While the

carriage 208/damping element 250 or ram 204/damping element25l continue. to.move away from

the puncture site the toothed rack 240 is held in position by the adjusting screw 230 and the toOthed rack by the adjusting screw 231, i.e. the toothed racks 240/241 move relative to the damping
elements 2501251 into the selected starting position.
5

The position of the limit-stop surfaces 230A/231 can be changed by means of the adjusting screws 230/231. The distances by which the toothed racks 240/241 move relative to the damping elements

10    2501251 is adjustable l;Jy the patient.

Figures 16A/16B show the adjusting screws 230 and 231 in the position that produces the maximum

retention time/injection duration.

15

Figures 17A/17B show the adjusting screws 230 and 231 in the position that produces the minimum retention time/injection duration. Between these two positions, the retention time (duration of the

20    idle stroke HX) and injection duration (duration of the injection stroke H2) may be adjusted continuously, independently from each ather.

After the mechanism has been moved back into the starting position, the syringe 211 can now be•

25
removed.

In the described exemplary embodiments it is accordingly possible for the user, so as to adjust the

duration of the injection stroke by means of an appropriate design of the damping element, to adjust
30

the duration of the effect of the damping element within a stroke by displacing the associated toothed rack. so that a portion of the .stroke proceeds undamped, the remaining portion damped.

3 5 Alternatively, a damping element may be used whose damping characteristics can be adjusted by the user to thereby vary the duration of the stroke.

Combinations of such measures for generating a desired process characteristic (speed profile) of a stroke are possible as well.

5    To implement these alternatives for a user-defmed adjustment of the speed/duration of a stroke, for

. instance. ~f the injection stroke, a rotation damping element of a commercially available type may be

. used in the described exemplary embodiments.

10

Advantageously, a rotation damping element may be used, such as the one described in DE 20.2006

017 578..3 U 1.  With the latter, it is possible to set a basic damping, permitting ~ even more flexible

adaptation of the progression profile of a stroke to the individual requirements of a user.

15

If the desired variation of the duration of the respective stroke is already attainable via the adjusting range of this basic damping provided by a rotation damping element according to DE 20 2006 017

20    578.3 Ul, the adjustment of the associated toothed rack by means of its associated acljusting screw may be dispensed with, if appropriate, and the same may then remain in the position in which it permits the maximum stroke duration.

Figures 18 and 19 show two exemplary embodiments of a damping element in which the coupling of the toothed rack, as the stroke-determining component, to one/two rotation damping element(s) is effected by means of a planetary gear that is designed, by means of a locking element, as an On/Off

switch for the rotation damping element. The components are supported and/or held in a housing 311,411.

The first exemplary embodiment shown in Figures 18A-18F is designed as follows:
The annulus gear 30 I and the planetary carrier 302 .of a planetary gear 300 are supported freely rotating on the shaft 303. The sun gear 305 is rigidly press-fitted to the shaft 303 and thus acts as a drive for the rotation damping element 304 connected to the shaft 303.

The planetary carrier 302 is rigidly connected via three axes 309 to the three planet gears 310. They rotate about the sun gear 305 via a toothing. The annulus gear 301 is driven via the toothed rack

306. A blocking slide 307 is able to prevent the planetary carrier 302 from turning by engaging intO its toothing. Depending on the position of the blocking slide 307, the respective gears ate operated in the following modes:
 

The planetary carrier 302 is not blocked (Figures 18C,E):

The blocking slide 307 is not blocking the planetary carrier 302. The annulus gear 301 rotates,

20    causing the planet gears 3 I 0 to rotate about the sun gear 305, thereby effecting a rotation of the planetary carrier 302 .. The sun gear 305, accordingly, is not moving and the rotation damping

element 304 is therefore not driven.  This means that an idle movement takes place, i.e. the stroke of

2 5 the injection device that is coupled to the toothed rack 306 proceeds undamped with maximum speed and therefore in the shortesJ amount of time.

-The planetary carri.er302 is blocked (Figures l8A,B,D,F):

30

The blocking slide 307 engages into the planetary carrier 302. The annulus gear 301 rotates because of the linear movement of the toothed rack 306. The annulus gear 301 drives the planet gears 310;
3 5 Since the planetary carrier 302 is fixed in its position, the individual planet gears 31 0 cannot rotate about the sun gear 305. The planet gears 310 accordingly drive the sun gear 305. Since the same is connected via the shaft 303 to the rotation damping element 304, the same is being driven. This
means that a damping takes place, i.e. the stroke of the injection device that is coupled to the toothed

rack 306 proceeds at a reduced speed/over .a longer duration:

5    If two rotation damping elements with different damping values that are placed in series are operated ill this fllllllll:er, a plurality of combinatioll& are possible:

I) None of the two blocking slides is depressed -+ idle movement, no stroke damping,

10    2) only one• blocking slide is ~ressed --+ only the associated rotation damping eieinent is   
       
    damping, stroke c4lmping based on the selected rotation damping element,   
    3) both blocki11g slides are depressed --+ both rotation damping elements are damping,   
15    maximum damping of the stroke.   
       
    The second example shown in Figures 19A-19H expands upon the frrst example and is designed as   
20    follows:   
       
    Two shafts 403A and 403B are provided. The first shaft 403A serves as a drive for the frrst rotation   
    damping element 404A.  Rigidly disposed on, e.g. pressed onto the first shaft 403A is a first   
    It   
2 5    blocking disk 408A.  The annulus gear $01 rotates freely on the first shaft 403A.  Additionally, the   
    s\in gear 405 is rigidly connected to the first shaft 403A. The drive is effected via the toothed rack   
    406, which drives.the annulus gear 401.   
30       
    The second shaft 403B serves as a drive for the second rotation damping element 404B.  Rigidly   
    disposed on the second shaft 403)3 -is.a second blQCking qisk. 408B. The second blocking disk 4088 •   
    serves as the planetary carrier, since the thr~ planet gears 410 are connected freely rotating Via the•   
35    Af"iie ~   
    three axes 409.  The planet gears 410 are driven via the annulus gear 401 and dri\tfjllle Tq§l)eCii!Vejj   

gears in dependence upon the position of the blocking slides 407 A,407B of the blae~•~uge. •

The following functions are thus created:

- The first blocking disk 408 is blocked (Figure 19C):

The blocking device blocks, via its first blocking slide 407 A, the rotation of the first blocking disk

408A and thereby the rotation of the first shaft 403A. The annulus gear 40 I rotates, due to the linear movement of the toothed rack 406, and drives the planet gears 410.

.Smce me nrst snan 4UJA cannot rotate, the sun gear 405 is fixed in its position. The planet gears 410 can therefore move about the sun gear 405, thereby driving the planetary carrier/sec~nd blocking disk 4088. Since the same is connected via the second shaft 4038 to the second rotation
 

damping element 4048, the second rotation damping element 4048 is being driven. A damping therefore takes place via the second rotation damping element 4048. (The second blocking disk
408B rotates without effect.)
20

- The second blocking disk 4088 is blocked (Figures 198,D,E):

The blocking device blocks, via its second blocking slide 4078, the rotation of the second blocking

25

disk 408B and accordingly the rotation of the second shaft 4038. The annulus wheel 401 rotates due to the linear movement of the toothed rack 406 and drives the planet gears 410. Since the planet
carrier(= second blocking disk 4088) is fixed in its position, the planet gears 410 cannot move
30

• about the sun gear 405.  The plane.t gears 410 accordingly drive the sun gear 405.  Sine~ the same is

. c.onnected .via the. first.shaft 403A to the first rotaticm damping element 404A, the same• is being •

driven.  A damping oHh~ stroke accordingly takes place via the first rotation datnplng element••

35

404A.  (The first blocking disk 408A rotates without effect.)

The components described under Figures 17 and 18 with the designations ''toothed rack 306,406 I

planetary gear set 300,400 I rotation damping element 304,404A,404B" may be used in the two

5 exemplary embodiments of the injection device depicted in Figures I through 16 in lieu of the component with the designations "toothed rack 140,240,241/ damping element I 50,250,251" that is shown there.

10
By connecting the blocking slides to actuation means outside the housing in a sliitablemanner1 a damping element can be activated or selected by the user, so as to, for example, achieve a slower injection stroke.
15

The patient is thereby given an added adjusting option for individually designing the progression profiles of the strokes of "his" injection device.

    Reference Numerals       
    housing    101,201   
    first push-button    102,202   
5    locking hook    102A,202A   
           
    receptacle    103,203   
    ram    104,204   
ilO    control lever    105,205   
           
    first adjusting slider    107,207   
    second adjusting slider    106,206   
15    ramp    106A,206A   
           
    limit stop    206B   
    carriage    108,208   
20    roller    109,209   
           
    spring    110,210   
    carpule    Ill   
. .d5    syringe    211   
           
    hypodermic cannula    112,212   
    traction cable    114,214   
30    pull rod    115,215   
           
    second ptish.:bution•    116   
    locking hook    116A   
35    pull-back handle    117,217   
           

driving feature    118,218   
driving spring    lt9,219   
pull-back spring    120,220   
blocking mechanism for receptacle    221
guide means for blocking mechanism    222
ramp    222A   
 

    spring    223   
    first adjusting screw    130,230   
15    second adjusting screw    231   
    first limit-stop surface    130A,230A   
    second limit-stop surface    231A   
20    first toothed rack    140,240   
    second toothed rack    241   
    first damping element    150,250   
25    second damping element    251   
           
    planetary gear    300,400   
    annulus gear    301,401   
30    planetary carrier    302,402   
           
    shaft    303,403A,403B   
    rotation damping element    304,404A,404B   
35    sun gear    305,405   
           
    toothed rack    306,406   
    blocking slide    307,407A,407B   
 
    blocking discs    408A,408B
    axes    309,409
5    planetary gears    310,410
    housing    311,411
What is claimed is:

I.    An injection device for accommodation and activation of a carpule (Ill) or hypodennic syringe

(211)    with an injection needle, and incorporating components whose relative movement effects

5    the sequence of injection of the active substance, for which purpose a receptacle (I 03, 203), into which the carpule/syringe (Ill, 211) is insertable and in which it is fixable, is supported inside

a housing (101, 201), and said receptacle (103, 203) is displaceable by means of a carriage (108,

i 0    208), and mounted in the receptacle (103, 203) in a manner so as to be displaceable is a ram

(104, 204), which actuates the piston(s) (lllA,IIIB; 211) of the carpule/syringe, and wherein a traction cable (114, 214) is provided for carrying out the puncture stroke, injection stroke and a

15    retraction stroke, which is deflected by means of a roller (109, 209) that is mounted on the carriage (108), one end of which is connected to the receptacle (103, 20~ri't~hd.:.elid' of.

which is connected to a tension spring (II 0, 21 0), the latter being supp!jt\fi:tl on the::Jtpusing

20    (101, 201), wherein automatically and/or manually activated devices b~e~n.the housing {l&t• 201), receptacle {103, 203), ram (104, 204) and carriage (108, 208) control ttreifliltematinl!: coupling to the traction cable (114, 214) and thereby the progression of puncture stroke,-
•-    injection stroke and retraction stroke, characterized in that the devices include at least one
25

means for adjustment of the progression profile of at least one of the strokes by the user.

2.  An injection device according to claim I, wherein the traction cable (114, il4) pulls the

30    receptacle (103,203) with the carpule/syringe and pulls the injection needle out of the puncture   
       
    site via the carriage (108,208) and roller (109,209) during the retraction stroke following the   
    injection stroke, characterized in that the duration of a movement-free state of the   
35    carpule/syringe between the injection stroke and retraction stroke (idle stroke!M), !lllrin!   
       
which the injection needle remains in the insertion site, is adjustable at the housing (101,201) by means of at least one fust means.

3.    An injection device according to claim I, wherein devices are provided for coupling the ram (104, 204) to the receptacle (103, 203), which couple the ram (104, 204) to the receptacle (103,
203)    for carrying out the puncture stroke and uncouple it for carrying out the injection stroke, characterized in that the dqration between .the beginning and end of the movement of the ram (104, 204) in the receptacle (103, 203) and thereby the duration of the injections stroke (H2) is adjustable by means of at least one second means.

4.    An injection device according to claim 2 or 3, characterized in that the frrst and/or second means includes a displaceably supported toothed rack (140,240,241).

5.    An injection device according to claim 2 or 3, characterized in that the first and/or second means

includes at least one damping element (150,250,251) that is actuatable from an associated

toothed rack ( 140,240,241 ).
 

6.    An injection device according to claims 4 and 5, characterized in that the duration of the effect of the damping element (150,250,251) is adjustable at the housing via a portion of the associated stroke (HX,H2) by means ofpositioners (130,230,231) that effect the displacement of the associated toothed rack {140,240,241) between two end positions.

7.    An injection device according to claim 6, characterized in that the damping element has a damping characteristic that is adjustable at the housing.
 
8.    An injection device according to claim 5, characterized in that the damping element is a rotation damping element (304,404A,404B) having a gear wheel on its shaft that is acted upon by a toothed rack ( 140,240,241 ).

9.    An injection device according to claim 8, characterized in that there is disposed between a rotation damping element and its toothed rack a gear mechanism.

10.    An injection device according .to claim 9, characterized in th~t the gear mechanism is a planetary gear (300), whose sun gear (305) is rigidly connected to the shaft (303) of the rotation
 

15    damping element (304), whose annulus gear (301), which is freely rotatable on the shaft (303) and in which planet gears revolve, intermeshes with the toothed rack, and whose planetary

carrier (302), which freely rotates on the shaft (303), can be put into engagement with a user-
 

20
 

activated blocking slide (307), wherein the same prevents the rotation of the planetary carrier
 

(302).

11. An injection device according to claim 10, characterized in that two rotation damping elements

25    (404A,404B) are held on shafts (403A,403B) that are disposed concentrically to each other, wherein the first shaft (403A) is rigidly connected to a first blocking disk (408A) and to the sun

gear (405), and the annulus gear (401) freely rotates about this first shaft (403A), wherein the

3 O second shaft (403B) is rigidly connected to the planetary carrier that is designed so as to form the second blocking disk (4088), and that a user-adjustable blocking element can alternatively block the rotation of one ofthe two blocking discs (408A,408B).
35

12.    An injection device according to claim 1, characterized in that when a carpule (Ill) is used, the punctlD'e stroke is preceded by a mixing stroke.

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