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(19)    (11) Patent Number: KE 292
(45) Date of grant: 12/01/2009
Kenya Industrial Property Institute,
(12) PATENT
(51) Int.C1.7: C 07D 277/40

(21)Application    PCT/FR2005/0017
Number:
(22)Filing Date:    05/01/2007
(31)Priority Number: 0407695 09/07/2004 FR (73) Owner(s):
SANOFI-AVENTIS of ,
174, avenue de France, F-75013 Paris, France    (84) WO No. W02006/016039
16/02/2006
(32) Date: (33) Country:
   

(72) Inventor(s)    CASELLAS, Pierre; FLOUTARD, Daniel; FRAISSE,
Pierre and JEGHAM, Samir
(74)Agent/address for correspondence: Kaplan & Stratton Advocates,
(54) Title:    2-CARBAMIDE-4-PHENYLTHIAZOLE DERIVATIVES, PREPARATION
THEREOF AND THERAPEUTIC USE THEREOF.
(57) Abstract: The invention concerns 2-carbamide-4-phenylthiazole derivatives of general formula (1). The invention also concerns pharmaceutical compositions containing a compound of general formula (1).
 
2—CARBAMIDE-4—PHENYLTHIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
The invention relates to 2-carbamide-4-phenylthiazole 5 derivatives, to the preparation thereof and to the therapeutic use thereof.
A subject of the invention is compounds corresponding to formula (I) below:
 

 
10    (I)
in which
-    (i)    R1 is selected from the group consisting of H,
halogen,    (C1-C8)alkyl,    trifluoro(Cl-C4)alkyl,    -OH,
-0-trifluoro (C1-C8) alkyl,    -0-
15 (C3-C10)cycloalkyl(C1-C8)alkyl, -0-(C3-C10)cycloalkylr -0- CH2-CH=CH2 and (C1-C4)alkylthio;
-(ii)    R2 is selected from the group consisting of H, halogen,    -OH,    (C1-C8) alkyl,    trifluoro (C1-C4) alkyl,
perfluoro (C1-C4) alkyl,    (C3-C10) cycloalkyl,
20 C8)alkyl,    -0- (C3-C10) cycloalkyl (C1-C8) alkyl,    -0- (C1-
 -0- (C3-

C10) cycloalkyl, -0-CH2-CH=CH2 and (C3-C8) cycloalkyl (C1-
 C8) alkyl;
-(iii)    Y represents a hydrogen atom or a halogen;
-    (iv)    R3 represents:
25
al) a group of formula -(CH2)p-A
in which p represents 0, 1, 2, 3 or 4, and:
-    when p represents 2, 3 or 4, A represents a group of
 
WO 2006/016039    2    PCT/FR2005/001729
formula:
 

 
-NR4R5,
in which R6 is selected from the group consisting of H,
5 F, (C1-C4) alkyl, - (CH2) n0H, - (CH2) no (C1-C4) alkyl and -(CH2)nliR4R5, where n represents 0, 1 or 2, and R4 and R5 represent, independently of one another, a hydrogen atom, or a (C1-C8)alkyl, -CO(Ci-C4)alkyl or -00-0- (C1-C8)alkyl group;
10 - or, when p represents 1, 2, 3 or 4, A represents a group of formula:
R7    R7    R7
,N∎ ,N∎    („r0,
     , or    ,R7
—N

in which R7 is selected from the group consisting of H, (C1-C8) alkyl,    -CO- (C1-C8) alkyl,    benzyl,    -00-0-(C1-
15 C8)alkyl, -00-0-benzyl, -CO-phenyl, -CO-heteroaryl, -CO¬( C3 -C10 ) CyCl Oa 1 kY1 -S02-(C1-C8)alkyl, -S02-(C3- C8)cycloalkyl and -S02-heteroaryl ;
- or, when p represents 0, 1, 2, 3 or 4, A represents a 20 group of formula:
 

 
said group being optionally substituted with a (C1-C4)¬alkyl group;
 
a2) a group of formula -(CH2)p-CO-A in which p represents 1, 2, 3 or 4, - A represents a group of formula:
 

 
5 -NR4R5,
in which R4, R5 and R6 are as defined above;
a3) a group of formula -CO(CH2) p-A
in which p represents 0, 1, 2, 3 or 4
10 - when p represents 1, 2, 3 or 4, A represents a group of formula:
/ \ —N 0
/
R6         —N
\    
R6    N
I A—R6    , or

-NPAR5,
in which R4, R5 and R6 are as defined above;
15 - or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
 
    R    R
    7    17    1 R
7
    ../ N    / ''
    N    N,
/
..,v.. 7
 
in which R7 is as defined above;
20 - or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
 
said group being optionally substituted with a (C1-C4)- alkyl group;
a4) a group -B
5 in which B represents a group of formula:
 
N—R7), or
 
in which R7 is as defined above; -(v)    a represents 2 or 3.
10 A preferred halogen is a fluorine.
The compounds of formula (I) may contain one or more
asymmetric carbon atoms. They may therefore exist in
the form of enantiomers or of diastereoisomers. These
15 enantiomers and diastereoisomers, and also mixtures thereof, including racemic mixtures, form part of the invention.
The compounds of formula (I) may exist in the form of 20 bases or of addition salts with acids. Such addition salts form part of the invention.
These    salts    are    advantageously    prepared    with
pharmaceutically acceptable acids, but the salts of
25 other acids that are useful, for example, for purifying
or isolating the compounds of formula (I) also form
 
part of the invention.
The compounds of formula (I) may also exist in the form
of hydrates or of solvates, i.e. in the form of
5 associations or combinations with one or more water molecules or with a solvent. Such hydrates and solvates also form part of the invention.
In the context of the present invention:
10    the term "Ct-z" where t and z may have the values
of 1 to 10, is intended to mean a carbon chain that may have from t to z carbon atoms, for example the term "Ci_3" is intended to mean a carbon chain that may have from 1 to 3 carbon atoms;
15 -    the term "Hal" is intended to mean a halogen atom
such as a fluorine, a chlorine, a bromine or an iodine;
-    the term "an alkyl group" is intended to mean a saturated,    linear    or    branched    aliphatic    group
optionally substituted with a halogen atom. By way of
20 examples, mention may be made of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, 2-fluoroethyl groups, etc.;
-    the term "a cycloalkyl group" is intended to mean a cyclic alkyl group. By way of examples, mention may
25 be made of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl groups, etc.;
-    the term "an alkoxy group" is intended to mean an
-    0-alkyl radical in which the alkyl group is as defined above;
30 -    the term "a heteroaryl group" is intended to mean
an aryl group carrying one or more hetero atoms, optionally substituted with another hetero atom. By way of examples, mention may be made of pyrazine,
 
pyrimidine, pyridazine, pyridine, triazine, triazole, thiazole, oxazole, pyrazole, imidazole, oxopyridine groups, etc.;
the term "a perfluoroalkyl group" is intended to 5 mean an alkyl radical, as defined above, for which all the carbon atoms are substituted with fluorine atoms.
Among the compounds which are subjects of the invention, mention may be made of a first group of 10 compounds of formula (I.a) below:
 

 
Compounds of the invention of formula (I.a) are those 15 in which R1 is in the 2-position and R2 is in the 5- position with respect to the phenyl.
Among the compounds which are subjects of the invention, mention may be made of a second group of 20 compounds of formula (I.b) below:
 
in which R1, R2, Y, p and A are as defined above.
 
Compounds of the invention of formula (I.b) are those in which R1 is in the 2-position and R2 is in the 5- position with respect to the phenyl.
5 Among the compounds which are subjects of the invention, mention may be made of a third group of compounds of formula (I.c) below:
     0
N) N//'
B

in which R1, R2, Y and B are as defined above.
10
Compounds of the invention of formula (I.c) are those in which R1 is in the 2-position and R2 is in the 5-position with respect to the phenyl.
15 Other compounds of the invention are those for which:
-    R1 represents a -O-(C1-C8)alkyl group and/or;
R2 represents a (C1-C8)alkyl,    (C3-C10) cycloalkyl,
perfluoro (C1-C4) alkyl or -0- (C1-C8) alkyl group.
20 Among the compounds of formula (I) of the invention, mention should in particular be made of the following compounds:
•    (R)-N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]- N'-[4-(1-methylpiperidin-3-ylmethyl)piperazin-l-yl]urea 25 (Compound No. 76),
•    N-[4-(2-methoxy-5-propoxyphenyl)thiazol-2-y1]-N'- [4-(2-morpholin-4-ylethyl)piperazin-l-yl]urea (Compound
 
No. 1),
•    N-[4-(2-methoxy-5-propylphenyl)thiazo1-2-y1]-Nf-[4- (3-piperidin-1-ylpropyl)piperazin-1-yl]urea    (Compound
No. 11),
5 •    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4-
(2-dimethylaminoethyl)piperazin-1-yl]urea    (Compound
No. 16), N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4-(2- oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]urea
10 (Compound No. 20),
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- (2-thiophen-2-ylethyl)piperazin-1-yl]urea    (Compound
No. 21),
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- 15 [2-(tetrahydrofuran-2-yl)ethyl]piperazin-1-yl]urea (Compound No. 22),
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- (2-pyrrolidin-1-ylacetyl)piperazin-1-yl]urea    (Compound
No. 31),
20 •    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4-
[2-(3-ethylaminopyrrolidin-1-yl)ethyl]piperazin-1-y1]- urea (Compound No. 33),
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(1-methylpiperidin-4-yl)piperazin-1-yl]urea
25 (Compound No. 47),
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(1-benzylpiperidin-3-yl)piperazin-1-yl]urea
(Compound No. 68),
•    N-[4-(2-methoxy-5-propylphenyl)thiazo1-2-y1]-Nf-[4- 30 (2-pyridin-4-ylethyl)piperazin-1-yl]urea    (Compound
No. 28),
•    N-[4-(2-methoxy-5-pentafluoroethylphenyl)thiazol-2- y1]-N'-[4-(2-pyrrolidin-1-ylethyl)piperazin-1-yl]urea
 
(Compound No. 29),
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(1-isopropylpiperidin-3-yl)piperazin-1-yl]urea (Compound No. 70),
    5 •    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'-
[4-(2-pyrrolidin-l-ylethyl)piperazin-1-yl]urea
(Compound No. 30),
•    N-[4-(5-cyclohexy1-2-methoxypheny1)-5-fluorothiazol¬2-y1]-N'-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]urea 10 (Compound No. 59),
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-W¬[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]urea (Compound No. 108),
•    N-[4-(5-cyclohexyl-2-ethoxyphenyl)thiazol-2-yl]-N'-
15 [4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]urea (Compound No. 109),
N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazo1-2-y1]-N'-
[4-(2-oxo-2-morpholino-4-ylethyl)piperazin-1-yl]urea (Compound No. 116),
    20 •    N-[4-(5-cyclohexy1-2-ethoxyphenyl)thiazol-2-y1]-W-
[4-(2-oxo-2-morpholino-4-ylethyl)piperazin-l-yl]urea (Compound No. 110),
•    (S) N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]- N'-[4-(1-sulphomethylpiperidin-3-ylmethyl)piperazin-1- 25 yl]urea (Compound No. 112),
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(1-oxo-1-(1-oxopyridin-2-yl)meth-1-ylpiperidin-3-yl-methyl)piperazin-1-yl]urea (Compound No. 113).
30 Some intermediates that are useful for preparing the compounds of formula (I) may also serve as a final product of formula (I), as will emerge in the examples given hereinafter.
 
Similarly, some compounds of formula (I) of the invention may serve as intermediates that are useful for preparing compounds of formula (I) according to the invention.
5
In the subsequent text, the expression "protective group Gp" is intended to mean a group that makes it possible, firstly, to protect a reactive function such as a hydroxyl or an amine during a synthesis and,
10 secondly, to regenerate the intact reactive function at the end of synthesis. Examples of protective groups and also methods of protection and of deprotection are given in "Protective Groups in Organic Synthesis", Green et al., 2nd edition (John Wiley & Sons, Inc., New
15 York).
In the subsequent text, the term "leaving group X" is
intended to mean a group that can be readily cleaved
from a molecule by breaking a heterolytic bond, with a
20 pair of electrons leaving. This group can thus be readily replaced with another group in a substitution reaction, for example. Such leaving groups are, for example, halogens or an activated hydroxyl group such as a mesyl, tosyl, triflate, acetyl, etc. Examples of
25 leaving groups and also references for the preparation thereof are given in "Advances in Organic Chemistry", J. March, 3rd Edition, Wiley Interscience, p. 310-316.
In the subsequent text, the expression "precursor of R1,
30 R2 or R3" is intended to mean a substituent R11, R'2 or R'3 that can be converted to R1, R2 and R3 by one or more chemical reactions.
 
In the subsequent text, the term "group Z" is intended
to mean a leaving group or a functional acid
derivative, such as an acid chloride, a mixed anhydride
or a symmetrical anhydride, or else the acid
5 opportunistically activated, for example, with benzo-
triazol-1-yloxytris(dimethylamino)phosphonium    hexa-
fluorophosphate(BOP),    0-benzotriazol-1-yl-N,N,N',N'-
tetramethyluronium    hexafluorophosphate    (HBTU)    or
0-benzotriazol-1-yl-N,N,W,N'-tetramethyluronium tetra-10 fluoroborate (TBTU).
When one or more substituents R'1, R'2 and/or R'3
represent a group containing an amine or hydroxyl
function,    these functions can be intermediately
15 protected: an amine function can be protected with an alkanoyl, benzyl, tert-butoxycarbonyl (Boc), benzyloxy-carbonyl or 9-fluorenylmethoxycarbonyl (Fmoc) group, for example; a hydroxyl function can be protected in the form of an ether or of an ester, for example.
20
The compounds of the invention can be prepared according to various methods described in the present patent application.
25 Before tackling these methods, the methods for preparing the aminothiazole derivatives of formula (II) and the methods for preparing the amine derivatives of formula (III), which are useful for preparing the compounds of formula (I) of the invention, are
30 described below.
The aminothiazole derivatives of formula (II) can be
prepared by known methods such as those described in
 
documents EP 518 731, EP 611 766 and WO 99/15525.
In general, when Y = H, thiourea is reacted with a halogenated ketone of formula 1 according to the 5 following reaction scheme:
 

 
The substituents R'1 and R'2 have the values indicated
above, i.e. R'1 and R'2 represent, respectively, R1 and
R2 as defined for the compound of general formula (I) or
10 groups that are precursors of R1 and R2; Hal represents a halogen atom, preferably bromine, chlorine or iodine.
As indicated on the above scheme, the compounds of type (II) with Y = H, R'1 and R'2 having the values indicated
15 above, can be converted into compounds of type (II) with Y = F and R'1 and R'2 having the values indicated above, by reaction with a fluorination agent, for example Selectfluor©, in a solvent such as DMF or DCM at a temperature ranging from 0°C to 50°C.
20
The halogenated ketones of formula 1 can be prepared by processes known to those skilled in the art. For example, the bromoketones can be obtained by reacting bromine, cupric bromide or phenyltrimethyl-
    25 ammoniumtribromide    (PTT)    with    an    acetophenone
derivative of formula:
 
 
2
in which R'1 and R'2 have the values indicated above, in an organic solvent such as ethyl acetate, a chlorinated solvent or a mixture thereof, or else an alcohol.
5
When the acetophenone derivative of formula 2 is not commercially available, it can be prepared by various methods:
-    a Friedel-Crafts reaction with benzene substituted
10 with R'l and R'2, which is reacted with acetyl chloride or acetic anhydride, in the presence of a Lewis acid such as AlC13 or TiCl4, for example;
-    the action of acetyl chloride, in the presence of
palladium, with benzene substituted with R'1 and R'2,
15 after deprotonation of the benzene, for example by the action of butyllithium and then addition of zinc chloride or of manganese iodide. This procedure can be used to prepare an acetophenone derivative of formula 2 in which R'2 = R2 = (C1-C4)perfluoroalkyl;
20 -    a Fries rearrangement: from an acetoxybenzene
derivative of formula:
O
CH3-C-0         3

by the action of a Lewis acid, a hydroxyacetophenone derivative is obtained, of formula:
 
The hydroxyl function corresponds. to a group R'1 which
can be converted, in a subsequent step, to a group -0-W
5 such as -0- (C1-C8) alkyl, trifluoromethoxy, trifluoroethoxy, allyloxy, (C3-C10)cycloalkylmethoxy or (C3-C10) cycloalkyloxy.
The conversion of R'1 to R1 can be carried out either on 10 the aminothiazole of formula (II), or on a compound of formula (I).
The benzene derivatives substituted with R'1 and R'2 are commercially available or are prepared by methods known 15 to those skilled in the art.
For example, to prepare a compound in which R1 is a group -0-W as defined above, the following procedure is carried out:
 

 
5    6
A halobenzene derivative can also be substituted according to the scheme below:
 
WO 2006/016039    15    PCT/FR2005/001729
 

 
In the specific case where R2 represents a (C1- C4)perfluoroalkyl, the procedure can also be carried out according to the reaction scheme below:
 

 
7    8
5
A subject of the invention is also the compounds of formula (II.a):
 
in which:
    10 -    R1 represents a halogen atom, or an -0-(C1-C8)alkyl
or (C3-C10) cycloalkyl (C1-C8) alkoxy group;
-    R2    represents    a(C1-C8)alkyl,
(C1-C8)alkoxY,
(C3-C10) cycloalkyl, trifluoro (C1-C4) alkyl or perfluoro-(C1-C4)alkyl group.
15
Examples of preparation of aminothiazole derivatives of formula (II) are given in the subsequent text.
 
The amine derivatives of formula (III) are known or can be prepared according to the methods described in particular in document WO 87/01706 or according to the methods described in the subsequent text.
5
In the subsequent text, the group A' represents a group that is a precursor of the group A or a group A as defined above.
10 The compounds of formula (III) in which R'3 represents a precursor group of R3 or a group R3 as defined above, and in which a is as defined above, are obtained from compounds of formula 9 by deprotection of the nitrogen of the piperazine or of the homopiperazine, protected
15 according to methods known to those skilled in the art or described in the literature (WO 03/104230 and WO 03/057145).
By way of example, the procedure may be carried out as 20 follows:
 

 
The compounds of formula 9 are commercial or can be synthesized from commercial compounds, according to 25 methods known to those skilled in the art.
Preparation 2.1
 
The compounds of formula 9 in which R'3 is a precursor group of R3, with R3 representing a group -(CH2)p-A, in which A represents:
/r---\
—N/
---N    0    --N
\    /
-- I N    / R4
.,R5
R6    R6    Re
5 and p is 2, 3 or 4, R4, R5 and R6 being as defined above, can be prepared by reaction of the compound 10 with A'H in the presence of a base such as K2CO3, triethylamine or caesium carbonate in a solvent such as THF, acetonitrile, toluene or DMF, at temperatures
10 ranging from 0°C to 150°C, so as to obtain the compound 11. The compound 11 can then be converted to a compound of formula 9 by reduction of the amide function, for example with LiA1H4, diisobutylaluminium hydride (Dibal), BH3 in THF, ether or toluene, at a temperature
15 of between 0°C and 70°C, so as to give the compound of formula 9 in which R3 represents -(CH2)p-A:
 

 
10    11    9
The compound of formula 10 can be prepared by reaction of a monoprotected piperazine or homopiperazine with a 20 reactant of formula 12 below:
 
in which Z represents a leaving group or a group derived from the activation of a carboxylic acid function and X represents a leaving group, in a solvent such as THF, acetonitrile, DMF, or dichloromethane in
5 the presence of a base such as K2CO3 or triethylamine and, when Z represents an -OH group, of a reactant that activates the acid function, such as BOP, TBTU or CDI, according to the scheme below:
Gp
(CHOa
//,     Gp 1
12    --.NZ(CH2).

X
O    P -1
10
Preparation 2.2
The compounds of formula 9 in which R'3 is a precursor group of R3, with R3 representing a -(CH2)p-A in which A represents:

IR, 7
I 7
/".         —N

9
and p represents 1, 2, 3 or 4, R7 being as defined above, can be prepared by reaction of the compound 13 with a monoprotected piperazine or homopiperazine in a solvent such as THF, acetonitrile, DMF or
20 dichloromethane in the presence of a base such as K2CO3 or triethylamine and, when Z represents an -OH group,
 
of a reactant that activates the acid function, such as BOP, TBTU or CDI, according to the scheme below:
 

 
13    11
5 The compound 11 obtained can then be converted to a compound of formula 9 according to the scheme described above.
The compound 13, when it is not commercially available,
10 can be obtained by homologation of the commercial carboxylic acid according to conventional methods such as reactions of Arndt-Eistert type (Tetrahedron Lett., 1979, 29, 2667; "Advances in Organic Chemistry", J. March, 3rd Edition, Wiley Interscience, p. 1405-1407),
15 according to the scheme below:
 

 
13
Preparation 2.3
The compounds of formula 9 in which R'3 represents a
group that is a precursor of the group R3, with R3
20 representing -(CH2)pCO-A as defined above, can be
obtained from the compounds of formula 14 in which Z is
as defined above, by reaction with A'H in the presence
 
of a base such as K2CO3, triethylamine or caesium carbonate and, when Z represents an -OH group, of a reactant that activates the acid function, such as BOP, TBTU or CDI, in a solvent such as, for example, THF,
5 acetonitrile or DMF, at temperatures ranging from 0°C to 150°C, according to the scheme below:
     Gp
A'H /NN
(CH2),
base ∎NZ 0 9

The compounds of formula 14, when they are not
commercially available, can be obtained from a
10 monoprotected piperazine or homopiperazine and the reactant 15 in which Z is as defined above, by acylation or peptide-type coupling in the presence of a base such as K2CO3, triethylamine or caesium carbonate or of a coupling reactant such as BOP, TBTU or CDI, in
15 a solvent such as, for example, THF, acetonitrile or DMF, at temperatures ranging from 0°C to 150°C, according to the scheme below:
 

 
15    16
The compound 16 is then converted by reduction of the 20 amide function with, for example, LiA1H4 in THF or ethyl
 
WO 2006/016039    21    PCT/FR2005/001729
ether at a temperature of between 0 and 50°C. The intermediate obtained is deprotected and then oxidized to the carboxylic acid 17, for example with Cr03 or with other reactants according to the methods described in
5 "Advances in Organic Chemistry", J. March, 3rd Edition, Wiley Interscience, p. 1537-1539, according to the scheme below:
 

 
The compound 17 is then optionally converted so as to 10 give a compound of formula 14, or is used in its acid form (Z = OH).
Alternatively, the compounds of formula 17 can be prepared by reaction of monoprotected piperazine or 15 homopiperazine with a reactant 18 of formula:
OR
X    18
p
in which X is as defined above and R represents a (C1-C4)alkyl group, by alkylation of the nitrogen in the presence of a base such as K2CO3, triethylamine or
20 caesium carbonate in a solvent such as THF, acetonitrile, toluene or DMF, at temperatures ranging from 25 to 150°C, according to the scheme below:
 

?Pi
C
//ACHO.    
18     
O
19
The compound 19 obtained is then converted to the acid of formula 17 by saponification or acid hydrolysis or any other method known to those skilled in the art.
Preparation 2.4
The compounds of formula 9 in which R'3 represents a group that is a precursor of the group R3, with R3 representing a group -CO(CH2)p-A, in which A represents:
/ 0 —N
\
Rs    Rs    R6
and p representing 1, 2, 3 or 4, and R4, R5 and R6 being as defined above, can be prepared using the method described in preparation 2.1 above.
15 Preparation 2.5
The compounds of formula 9 in which R'3 represents a group that is a precursor of the group R3, with R3 representing a group -CO(CH2)p-A, in which A represents:
 
1\1    0    )7
4)      -FT
and p representing 0, 1, 2, 3 or 4, and R7 being as defined above, can be prepared using the method described in preparation 2.1 above.
5
Preparation 2.6
The compounds of formula 9 in which R'3 represents a
group that is a precursor of the group R3, with R3
representing a group -B, can be prepared by reaction of
10 a monoprotected piperazine or homopiperazine and of a ketone B' that is a precursor of B, by means of a reductive amination reaction in the presence of a reducing agent such as NaHB(0Ac)3, NaBH3CN in a solvent such as 1,2-dichloroethane, dichloromethane or THE at
15 temperatures ranging from 0°C to 70°C (Synth. Commun., 1998, 28 (10), 1897-1905, J. Org. Chem., 1992, 57 (11), 3218-3225, J. Org. Chem., 1996, 61, 3849-3862, Tetrahedron Lett., 1990, 31, 5595-5598), according to the scheme below:
    Gp
(CH2).
,
H    NaHB(OAc)3     
20        B'   
 
The ketones B' used are commercial or can be synthesized according to the method described in J. Org. Chem., 1989, 54, 1249-1256.
5 The compounds of formula (I) of the invention can be prepared according to general scheme 1 below:
Scheme 1
 

 
According to scheme 1, the compounds of the invention
10 are obtained by coupling the aminothiazole derivative of formula (II) in which R1, R2 and Y are as defined above, with an amine derivative of formula (III) in which R'3 represents a precursor group of R3 or a group R3 as defined above, and a is as defined above.
15
According to scheme 1, the aminothiazole derivative of formula (II) is placed in the presence of a coupling agent for a period of 2 to 16 hours, and then with the amine derivative of formula (III) for a period of 0.5
20 to 4 hours.
The coupling agent can be chosen from those that are
 
known to those skilled in the art, for phosgene,    di-(N-succinimidyl)carbonate
25 1,1'-carbonyldiimidazole, according to the
described in "Encyclopedia of Reagents Synthesis", L.A. Paquette, volume 2, p. 1006; p. 2304; volume 6, p. 4107.
 
example
or
methods
Organic
volume 4,
 
The reaction can be carried out in various solvents, for example dichloromethane, dimethylformamide or toluene, in the presence of a base such as triethylamine or K2CO3, at a temperature ranging from
5 0°C to 100°C.
The compounds of the invention of formula (I) in which
R3 represents a group -CO(CH2)p-A (or -CO(CH2)p-A') in
which A and p are as defined above and A' represents a
10 precursor group of A, can also be prepared according to scheme below.
Scheme 2
According to scheme 2, the aminothiazole derivative of
15 formula (VIII) in which R1, R2, Y, a and p are as defined above and X represents a leaving group is reacted with a group A'H that is a precursor of the group A or a group AH as defined above, to give the compound of formula (XII) (compound of formula (I) in
20 which R3 represents a group -CO(CH2)p-A) .
The reaction is carried out in a solvent such as
tetrahydrofuran or dimethylformamide in the presence of
a base such as triethylamine or K2CO3, at temperatures
25 ranging from ambient temperature to 150°C, for a period of 1 to 24 hours.
The compounds of the invention of formula (I) in which
R3 represents a group -(CH2)p-A can be prepared in the
 
known manner, from the compound of formula (XII) as defined above, directly by reduction of the carbonyl function with a reducing agent such as Red-Al or LiA1H4 according to scheme 3 below:
5    Scheme 3
 

 
compound of formula (I) with R3 =-(C1-12)p-A
Alternatively, the compounds of formula (I) can be
prepared from the compound of formula (XII) in which
the group A is protected prior to the reducing
10 reaction, in particular when the group A contains functions that are incompatible with the type of reducing agent used. After reduction, a compound of formula (I) is then obtained by deprotection of the group A and optional functionalization of the group A.
15
The compounds of formula (VIII) can be prepared according to scheme 4 below:
 
WO 2006/016039    27    PCT/FR2005/001729
Scheme 4
 

 
NM
NO
According to scheme 4, the aminothiazole derivative of
formula (II) as defined above is coupled to an amine
5 derivative of formula (IV) in which Gp represents a protective group, for example a benzyl or Boc group, and a is as defined above, to give the compound of formula (V).
10 The reaction is carried out under the same conditions as those described above for scheme 1.
The compound of formula (V) is then deprotected, according to the methods known to those skilled in the
15 art, to give the compound of formula (VI), which is reacted with the compound of formula (VII) in which Z represents a leaving group or a group derived from the activation of a carboxylic acid function and X represents a leaving group, to give the compound of
20 formula (VIII) in which RI, R2, Y, X and a are as defined above.
 
Alternatively, the compounds of formula (VIII) can be prepared according to scheme 5 below.
Scheme 5
r,NGR„.„.(cHoa    r- NGIa\s,
     L_    ,.„,„(CH2).
NH-Gp CHNN,
X    /X
(C H2) p    (CH2)p
(IX)    (X)
 

 
5 According to scheme 5, the compound of formula (VII) in which X is as defined above and Z represents a leaving group or a group derived from the activation of a carboxylic acid function can be coupled to the compound of formula (IV) by acylation or peptide-type coupling
10 in the presence of a base such as K2CO3, triethylamine or caesium carbonate or of a coupling reactant such as BOP, TBTU or CDI, in a solvent such as, for example, THF, acetonitrile or DMF, at temperatures ranging from 0°C to 150°C. The compound (IX) is thus obtained. The
15 compound (X), obtained by deprotection of the compound (IX), is then coupled with an aminothiazole compound of formula (II) under conditions identical to those of scheme 1.
20 In the general synthesis schemes, the starting compounds and the reactants, when the method for
 
preparing them is not described, are commercially available or are described in the literature, or else can be prepared according to methods that are described therein or that are known to those skilled in the art.
5
The examples that follow describe the preparation of compounds in accordance, with the invention. These compounds are not limiting and merely illustrate the present invention. The numbers of the compounds
10 exemplified refer to those given in Table II, which illustrates the chemical structures and the physical properties of some compounds according to the invention.
15 In the preparations and examples that follow:
-    CyHex = a cyclohexyl group;
-    AT = ambient temperature;
-    DCM = dichloromethane
-    DSC = di-(N-succinimidyl)carbonate
20 - DIPEA = diisopropylethylamine
-    THE = tetrahydrofuran
-    BOP    =    benzotriazol-1-yloxytris(dimethylamino)-
phosphonium hexafluorophosphate
-    Mp = melting point
25 - CDI = 1,1'-carbonyldiimidazole
-    DMF = dimethylformamide
-    DCE = dichloroethane
-    TFA = trifluoroacetic acid
-    Red-al® = sodium bis(2-methoxyethoxy)aluminium hydride 30 - TBNE = tert-butyl methyl ether
-    TBTU = 2-(1H-benzotriazol-1-y1)-1,1,3,3-tetramethyl¬uronium tetrafluoroborate
 
Preparation    of    aminothiazole    derivatives    of
formula (II)
Compounds of formula (II) in which:
Y represents -H (preparations 1.1 to 1.25),
R1 and R2 are in the 2-position and 5-position, respectively, with respect to the phenyl.
Preparation 1.1  4-(2-Methoxy-5-propoxypheny1)-1,3-thiazol-2-amine 10 A)    1-(2-Hydroxy-5-propoxyphenyl)ethanone
10 g of 2,5-dihydroxyacetophenone suspended in 100 ml of acetone are placed in a 500 ml round-bottomed flask, and 9.14 g of anhydrous K2CO3 are added, followed by
15 12.4 g of propyl iodide. The reaction medium is refluxed for 30 hours. After a return to ambient temperature, the medium is filtered through Celite® and then concentrated. The brown oil obtained is taken up in EtOAc, filtered, and washed with water, with a 2M
20 HC1 solution and then with a saturated NaCl solution. The organic phase is evaporated off to give a black paste. The paste is taken up in chloroform and filtered. The medium is concentrated to give 11.4 g of a black solid. The latter is taken up in absolute
25 ethanol. The solution is placed in a freezer for 10 minutes, and a solid precipitates and is collected by filtration. The filtrate is concentrated, taken up in ethanol, cooled in a freezer, and then filtered again. This operation is repeated 4 times to give 8.35 g of
30 the expected compound in the form of a powder.
B)    1-(2-Methoxy-5-propoxyphenyl)ethanone
49.8 g of K2003 followed by 22.4 ml of methyl iodide are
 
added to a solution of 35 g of the solid above in 350 ml of DMF. The reaction medium is heated for 12 hours at 60°C. After a return to ambient temperature, the medium is filtered through Celite®, diluted in ether and
5 washed with a 2M HC1 solution. The aqueous phase is extracted twice in ether. The combined organic phases are washed with a dilute sodium hydroxide solution, and then washed with water, twice, and with a saturated NaC1 solution. The organic phase is dried over MgSO4,
10 and then evaporated to give 35.55 g of a brown oil. The oil is distilled under reduced pressure at 115°C, to give 32.8 g of the expected compound in the form of an oil.
C)    2-Bromo-1-(2-methoxy-5-propoxyphenyl)ethanone 15
4.8 ml of bromine are added dropwise to a solution of 16.4 g of the oil obtained in the previous step, in 100 ml of methanol. The medium is stirred for 30 minutes at ambient temperature and then evaporated. The oil
20 obtained is taken up in dichloromethane, washed 3 times in water, then dried over MgSO4 and evaporated to give 24.5 g of a brown oil.
D)    4-(2-Methoxy-5-propoxypheny1)-1,3-thiazol-2-amine
25 24.5 g of thiourea are added to a solution of 42 g of the bromoketone prepared in the previous step, in 200 ml of ethanol. The medium is refluxed for 1 hour 30 minutes. The medium is then placed in a refrigerator for 12 hours, and then filtered. The solid thus
30 collected is rinsed with a small amount of cold ethanol, and then with ether. 25 g of hydrobromide are recovered.
 
The solid is suspended in a water/dichloromethane mixture and a return to the base is achieved by adding sodium hydroxide. The aqueous phase is extracted twice in dichloromethane. The combined organic phases are
5 dried over MgSO4 and then evaporated. The oil obtained is chromatographed on silica gel, to give 12 g of the expected product in the form of a powder.
Mp = 76°C
10 Preparation 1.2  4-(5-Butyl-2-methoxypheny1)-1,3-thiazol-2-amine
A)    4-Butylphenyl acetate
A solution of 10 g of 4-n-butylphenol, 10 ml of Ac20 and
15 8 ml of pyridine is stirred at reflux in 10 ml of dichloromethane. After 2 hours, the medium is cooled to ambient temperature, diluted in dichloromethane, washed with water, washed with a 1M HC1 solution, washed in a saturated CuSO4 solution, washed with water, and dried
20 over MgSO4. After evaporation, 10.8 g of the expected compound are recovered in the form of an oil.
B)    1-(5-Butyl-2-hydroxyphenyl)ethanone
3.22 g of A1C13 are added, in several portions, to 5 g
25 of the oil obtained in the previous step, in a 100 ml
round-bottomed flask. The medium is heated at 130°C for
1 hour. After a return to ambient temperature, a
solution of ice-cold water acidified with 35% HC1 is
run into the reaction crude. The medium is placed in an
30 ultrasound bath. EtOAc is added so as to obtain
solubilization of the medium after 15 minutes. The
aqueous phase is extracted 3 times in EtOAc, and the
organic phases are washed with water and then with a
 
saturated NaCl solution. After drying over MgSO4 and evaporation, 4.5 g of a yellow oil are recovered.
C)    1-(5-Butyl-2-methoxyphenyl)ethanone
5 1.44 g of K2CO3 followed by 0.648 ml of methyl iodide are added to a solution of 1 g of the oil obtained in the previous step, in 10 ml of DMF. The medium is heated at 60°C overnight. After a return to ambient temperature, the medium is filtered through Celite®,
10 diluted in ether and washed with a 2M HC1 solution. The aqueous phase is extracted twice in ether. The combined organic phases are washed with a dilute sodium hydroxide solution and then washed with water, twice, and with a saturated NaCl solution. The organic phase
15 is dried over MgSO4 and then evaporated, to give 1.27 g of a brown oil. The oil is purified by chromatography, to give 0.66 g of the expected compound.
D)    4-(5-Butyl-2-methoxyphenyl)-1,3-thiazol-2-amine
20 0.19 ml of bromine is added to a solution of 0.66 g of the product of the previous step, in 10 ml of methanol. The medium is stirred for 10 minutes, and then evaporated and taken up in dichloromethane. The organic phase is washed 3 times with water, and then dried over
25 MgSO4. 0.79 g of the expected product is recovered after evaporation. This compound is dissolved in 5 ml of ethanol in the presence of 0.46 g of thiourea and the medium is refluxed for 2 hours 30 minutes. A solid precipitates during the return to ambient temperature.
30 The solid thus collected is rinsed with a small amount of cold ethanol and then with ether. 0.6 g of the hydrobromide is thus recovered.
 
The solid is suspended in a water/dichloromethane mixture and a return to the base is achieved by adding sodium hydroxide. The aqueous phase is extracted twice in dichloromethane. The combined organic phases are
5 dried over MgSO4 and then evaporated, to give 0.34 g of a yellow oil that crystallizes slowly. The mother liquors are evaporated and then stirred in a water/dichloromethane mixture and a return to the base is achieved by adding sodium hydroxide. The aqueous
10 phase is extracted twice in dichloromethane. The combined organic phases are dried over MgSO4 and then evaporated. The oil obtained is chromatographed on
silica gel, to give 0.18 g of the expected compound. Mp = 48°C.
15
Preparation 1.22
4-(5-Pentafluroethy1-2-methoxypheny1)-1,3-thiazol-2- amine
A    1-Methoxy-4-pentafluoroethylbenzene
20
8.3 g of potassium pentafluoropropionate and 9.8 g of
CuI are introduced, under an inert atmosphere, into a
500 ml three-necked flask equipped with a Dean-Starck
apparatus and a condenser. 90 ml of DMF and 110 ml of
25 toluene are added. The medium is heated to 140°C under
nitrogen; 80 ml of toluene are distilled. The medium is
then cooled to AT and then deoxygenated with nitrogen
bubbling. 6 g of iodoanisole are then added and the
medium is heated at 155°C for 20 h. After a return to
30 AT, the medium is diluted in 200 ml of a water/ethyl
ether mixture. The medium is then filtered through
Celite®. The organic phase is washed 3 times with water,
dried over MgSO4 and then evaporated, to give 4.3 g of a
 
brown oil.
B)    1-(2-Methoxy-5-pentafluoroethylphenyl)ethanone
7.4 ml of BuLi at 2.5M in hexane are added, at -70°C,
5 to a solution of 3.5 g of 1-methoxy-4-penta-fluoroethylbenzene in 50 ml of anhydrous THF. The medium is stirred at -70°C for 30 min and then at 0°C for 45 min. 15.5 ml of a 1M solution of zinc chloride in ether are then added. After stirring at 0°C for
10 10 min, 1.33 ml of acetyl chloride are added. The medium is then deoxygenated with nitrogen, and 332 mg of palladium benzyl(chloro)bis(triphenylphosphine) in 5 ml of anhydrous THF are introduced. The medium is stirred at 0°C for 2 h 30 min and then at AT for 72
15 hours. The medium is run into a 2.5M HC1 solution and then extracted in ether. The organic phase is washed with NaHCO3 at 5% in water, with water, and then with a saturated NaCl solution. After drying over MgSO4 and evaporation, the crude is purified by flash
20 chromatography on silica, to give 2.25 g of a white solid.
Mp = 47°C.
C)    4-(2-Methoxy-5-pentafluorophenyl)thiazol-2-ylamine
25 0.5 ml of bromine in solution in 8 ml of methanol is
added to a solution of 2.25 g of the product obtained
in the previous step, in 10 ml of methanol. The medium
is stirred for 10 min and then evaporated and taken up
in dichloromethane. The organic phase is washed 3 times
30 with water and then dried over MgSO4. 2.63 g of the
brominated product are obtained after evaporation. This
compound is dissolved in 15 ml of methanol in the
presence of 1.25 g of thiourea, and the medium is
 
refluxed for 2 h. A solid precipitates during the return to AT. The solid thus collected is rinsed with ethyl ether. The solid is suspended in a water/dichloromethane mixture and a return to the base
5 is achieved by adding sodium hydroxide. The aqueous phase is extracted twice in dichloromethane. The combined organic phases are dried over MgSO4 and then evaporated, to give 1.63 g of a yellow solid.
Mp = 125°C
10
Preparation 1.3
4-(5-Cyclohexy1-2-methoxypheny1)-1,3-thiazol-2-amine
A)    7.84 g of K2CO3 followed by 3.53 ml of methyl iodide are added to a solution of 5 g of 4-cyclohexyl-
15 phenol in 60 ml of DMF. The medium is heated at 60°C overnight. After a return to ambient temperature, the medium is filtered through Celite®, and then diluted in ether and hydrolysed with water. The aqueous phase is acidified and then extracted in 3 times 50 ml of ether.
20 The combined organic phases are washed with a dilute sodium hydroxide solution, and then washed with water, twice, and with a saturated NaC1 solution. The organic phase is dried over MgSO4 and then evaporated, to give 4.31 g of the expected compound in the form of a solid.
25 Mp = 67°C.
B)    1-(5-Cyclohexy1-2-methoxyphenyl)ethanone
A suspension of 5.6 g of A1C13 in 40 ml of
dichloromethane is cooled to -10°C. 3 ml of AcCl and
30 4 g of the compound of the previous step are added. The
medium is stirred for 1 hour at -10°C, and then poured
into a beaker containing ice mixed with 35% HC1. After
separation by settling out, the combined organic phases
 
are dried over MgSO4 and then evaporated, to give 4.54 g of the expected product.
    C)    4-(5-Cyclohexy1-2-methoxypheny1)-1,3-thiazol-2-
amine
5
1.16 ml of bromine are added, dropwise, to a solution of 4.5 g of the product of the previous step, in 25 ml of methanol. The medium is stirred at ambient temperature for 30 minutes, and then becomes very
10 viscous. 5 ml of methanol are added, followed by 3.23 g of thiourea. The medium is refluxed for 2 hours. After a return to ambient temperature, a solid precipitates. The solid is collected, and then rinsed with a small amount of cold methanol. The solid is suspended in a
15 water/dichloromethane mixture and a return to the base is achieved by adding sodium hydroxide. The aqueous phase is extracted twice in dichloromethane. The combined organic phases are dried over MgSO4 and then evaporated, to give 3.33 g of the expected compound in
20 the form of a solid.
Mp = 113°C.
Preparation 1.4  4-(2-Methoxy-5-propylphenyl)-1,3-thiazol-2-amine
    25 A)    1-(2-Methoxy-5-propylphenyl)ethanone
A suspension of 10.6 g of A1C13 in 150 ml of
dichloromethane is cooled to -10°C. 5.7 ml of AcC1 and
6 g of 4-propylanisole are added. The medium is stirred
30 at -10°C for 30 min, and then poured into a beaker
containing ice mixed with 35% HC1. After separation by
settling out, the aqueous phase is extracted 3 times in
dichloromethane, and the combined organic phases are
 
washed with water and with a saturated NaCl solution, dried over MgSO4 and then evaporated, to give 7.86 g of a brown oil (quant.).
B)    2-Bromo-1-(2-methoxy-5-propylphenyl)ethanone 5
2.46 ml of bromine diluted in 40 ml of methanol are added, dropwise, to a solution of 7.86 g of the compound obtained in the previous step, in 80 ml of methanol. The medium is stirred at AT for 30 min, and
10 then evaporated. The oil obtained is taken up in dichloromethane, washed 3 times in water and then dried over MgSO4 and evaporated, to give 11.25 g (quant.) of a yellow oil.
C)    4-(2-Methoxy-5-propylpheny1)-1,3-thiazol-2-amine 15
4.94 g of thiourea are added to a solution of 8 g of the compound obtained in the previous step, in 60 ml of ethanol. The medium is refluxed for 1 h 30 min. The medium is then placed in a refrigerator for 12 h and
20 then filtered. The solid thus collected is rinsed with a small amount of cold ethanol and then with ether. The procedure is repeated a second time. The solid is suspended in a water/dichloromethane mixture and a return to the base is achieved by adding sodium
25 hydroxide. The aqueous phase is extracted twice with dichloromethane. The combined organic phases are dried over MgSO4 and then evaporated, to give 4.89 g of a brown oil that crystallizes slowly (67%).
30 The mother liquors are evaporated and then stirred in a water/dichloromethane mixture and a return to the base is achieved by adding sodium hydroxide. The aqueous phase is extracted twice in dichloromethane. The
 
combined organic phases are dried over MgSO4 and then evaporated. The oil obtained is chromatographed on silica gel, to give 580 mg of the expected product. Yield (total): 75%
Mp = 84°C
The compounds of formula (II) described in Table I below are prepared according to the procedures above.
 
Table I
 
Preparation No.    R1    R2    Salt    Mp(°C)
M
1.1    -OMe    -OPr    -    mp= 76°C
1.2    -OMe    -nBu    -    Mp = 48°C
1.2a    -OMe    -nBu    HBr    Mp= 186°C
1.3    -OMe        -    Mp= 113°C
1.4    -OMe    -nPr    -    Mp = 84°C
1.5    -OEt    -Et    -    Mp = 83°C
1.6    -OMe    -Et    -    Mp = 100°C
1.7    -OEt    -0    -    Mp= 110°C
1.8    -OMe            -    Mp = 110°C
1.9    -OEt    -nBu        Mp = 65°C
 
WO 2006/016039    41    PCT/FR2005/001729
Table I (continued)
Preparation No.    R1    R2    Salt    Mp (°C)
M
1.10    -OMe    CF3    -    Mp= 144°C
1.11    -OMe    -iPr    -    Mp = 109°C
1.12    -OMe    -Me    -    Mp= 121°C
1.13    zcH,
-0    -nBu    -    Mp= 59°C
1.14    -OMe    —CH.......CH2-CH3 ..'sCH2-CH3    -    MP= 91-93°C
1.16    -CI    CF3    -    Mp = 110°C
1.17    -OEt    Me    -    Mp = 124°C
1.18    -OMe    -CH(nPr)2    HCI    MH+ = 305.4
t=7.61
1.19    -OnPr    -nBu    -    Mp= 63°C
1.20    -OMe    -nHex    -    Mp = 43°C
1.21    -OEt    -nHex    -    Mp= 75°C
1.22    -OMe    CF3CF2    -    Mp = 125°C
1.23    -OEt    CF3CF2    -    MI-1+ = 338
t=7.88
 
Table I (continued)
Preparation No.    R1    R2    Salt    Mp (°C)
M
1.24    -OEt    -nPr    -    Mp = 87°C
1.25    -OEt    cyclopentyl    -    Mp = 128°C
 
Preparation    of    aminothiazole    derivatives    of
formula (II)
Compounds of formula (II) in which:
Y represents a fluorine atom (preparations 1.26 and 5    1.27),
R1 and R2 are in the 2-position and 5-position, respectively, with respect to the phenyl.
Preparation 1.26
10 4-(5-Cyclohexy1-2-methoxypheny1)-5-fluorothiazol-2-yl¬amine
3.4 g of Selectfluor© are added to a solution of 2.5 g
of the compound obtained in preparation 1.3 described
15 above, in 30 ml of DMF, and the medium is stirred at AT for 2 h. The medium is hydrolysed with 2M ammonia in ethanol, concentrated, and then diluted in water. The crude is filtered, and the solid is taken up in DCM and washed with water, then with 1M sodium hydroxide and
20 with a saturated NaC1 solution. After drying of the organic phase over MgSO4 and evaporation, the crude is purified by flash chromatography.
600 mg of the expected product are obtained in the form 25 of a white powder.
Mp = 159°C
Preparation 1.27  4-(5-Propy1-2-methoxypheny1)-5-fluorothiazol-2-ylamine
30
The compound is prepared according to preparation 1.26, from the compound of preparation 1.4.
Mp = 107°C
 
Elemental analysis:
%C 59.06 (theoretical 58.63)
%H 5.85 (theoretical 5.68)
%N 10.22 (theoretical 10.52)
5
Example 1: (Compound No. 9) N-[4-(2-methoxy-5-propyl-
phenyl)thiazol-2-y1]-N'-4-(3-morpholin-4-ylpropy1)- piperazin-1-yllurea
Compound of general formula (I) in which:
10 R1 = 2-OMe; R2 = 5-nPr; R3 = 3-(morpholin-4-ylpropyl); a = 2
 
1.1. Preparation of N-[4-(2-methoxy-5-propylpheny1)-  thiazol-2-y1]-N'-[4-(3-morpholin-4-ylpropyl)piperazin-
15 1-yl]urea
0.18 g of DSC is added to a solution of 0.1 g of 4-(2- (methoxy-5-propylpheny1)-1,3-thiazol-2-amine, obtained in preparation 1.4 above, in 2 ml of DMF, and the
20 medium is stirred at AT for 12 hours. 0.05 g of 1-(morpholin-4-ylpropyl)piperazine is added and the medium is stirred at AT for 3 hours. The medium is hydrolysed with a saturated NaHCO3 solution and then extracted in DCM. The organic phase is washed with
25 water and then with a saturated NaC1 solution, and then concentrated. After drying over MgSO4, the solution is concentrated and purified by flash chromatography on silica gel. The solid is taken up in DCM and treated with a 2M solution of HC1 in ether, and the suspension
 
is then evaporated, to give 0.077 g of the expected compound in the form of its hydrochloride.
Mp = 229°C
5 Example 2: (Compound No. 35) N-[4-(2-methoxy-5-propyl-phenyl)thiazol-2-yl]-N'-[4-[2-(3-ethylaminopyrrolidin-l-y1)ethyl]-[1,4]diazepan-l-yl]urea
Compound of general formula (I) in which:
R1 = 2-0CH3; R2 = 5-(CH2)2CH3; R3 = 4-[2-(3-ethylamino¬10 pyrrolidin-l-yl)ethyl]; a = 3
 
2.1 Preparation of N-[4-(2-methoxy-5-propylpheny1)-  thiazol-2-y1]-N'-[4-(2-chloroacety1)-[1,4]diazepan-l-yl]urea
15
4 g of DSC are added to a solution of 3.87 g of 4-(2- (methoxy-5-propylpheny1)-1,3-thiazol-2-amine, obtained in preparation 1.4 above, in 60 ml of DCM, and the medium is stirred at AT for 12 hours. 5.7 g of
20 2-chloro-1-[1,4]diazepan-l-ylethanone and 3.26 ml of triethylamine are added. The medium is stirred at AT for 3 hours. The medium is hydrolysed with a saturated NaHCO3 solution and then extracted in DCM. The organic phase is washed with water and then with brine, and
25 then concentrated. After drying over MgSO4, the solution is concentrated, to give 5.9 g of the expected compound.
MH+ = 452 at t = 8.53 min
 
2.2. Preparation of N-[4-(2-methoxy-5-propylpheny1)-  thiazol-2-y1]-N'-[4-[2-(3-acetylaminopyrrolidin-l-y1)-  acetyl]-[1,4]diazepan-1-yl]urea (Compound No. 32)  Compound of general formula (I) in which:
5 R1 = 2-OCH3; R2 = 5-(CH2)2CH3; R3 = 4-[2-(3-acetylamino¬pyrrolidin-l-yl)acetyl; a = 3
0.62 g of 3-acetamidopyrrolidine followed by 0.612 g of
K2CO3    are    added    to    a    solution    of    2 g    of
10 4-(2-chloroacetyl)-[1,4]diazepane-1-carboxylic    acid
[4-(2-methoxy-5-propylphenyl)thiazol-2-yl]amide
prepared in step 2.1, in 10 ml of acetonitrile. The medium is stirred at AT for 48 h. After filtration, the medium is washed with a 1M NaOH solution and then with
15 water and with a saturated NaC1 solution. After drying over MgSO4, the solution is concentrated and then purified by flash chromatography, to give 0.95 g of the expected product.
EA: %C = 56.94    %H = 6.89    %N = 14.52 (21-120)
20 MH+ = 543 at t = 5.85 min.
2.3. Preparation of N-[4-(2-methoxy-5-propylpheny1)-  thiazol-2-y1]-N'-[4-[2-(3-ethylaminopyrrolidin-l-y1)-  ethy1]-[1,4]diazepan-l-yl]urea
25 2.2 ml of a 65% solution of Red-al in toluene are added,    at    0°C,    to a solution of 0.79 g    of
4-[2-(3-acetylaminopyrrolidin-l-yl)acetyl]-[1,4]-
diazepane-l-carboxylic    acid    [4-(2-methoxy-5-propyl-
phenyl)thiazol-2-yl]amide prepared in step 2.2, in 3 ml
30 of DCM. After stirring at AT for 3 hours, the medium is concentrated and then taken up in DCM and washed with 1M sodium hydroxide, with water, and then with a saturated NaCl solution. After drying over MgSO4, the
 
organic phase is concentrated and then purified by flash chromatography, to give 0.27 g of the expected product.
MH+ = 515 at t = 8.77 min
5
Example 3: (Compound No. 76) (R)-N-[4-(5-cyclohexy1-2- methoxyphenyl)thiazol-2-y1]-N'-[4-(1-methylpiperidin-3- ylmethyl)piperazin-1-yl]urea
Compound of formula (I) in which:
10 R1 = 2-OCH3; R2 = 5-CyHex; R3 = (R)-4-(1-methylpiperidin¬3-ylmethyl); a = 2
 
3.1. Preparation of (R)-3-methanesulphonyloxymethyl¬piperidine-1-carboxylic acid tert-butyl ester
15
2.16 ml of methanesulphonyl chloride followed by 3.86 ml of triethylamine are added to a solution of 5 g of (R)-3-hydroxymethylpiperidine-l-carboxylic acid tert¬butyl ester in 80 ml of DCM cooled to 0°C. The medium
20 is stirred at 0°C for 1 h 30 min and 0.7 ml of triethylamine and 0.54 ml of methanesulphonyl chloride are again added. After 30 min at 0°C, the medium is hydrolysed, and the organic phase is washed twice in water and then with a saturated NaC1 solution, and then
25 dried over MgSO4. The medium is evaporated, to give 6.8 g of a pale yellow oil.
 
3.2.    Preparation    of    (R)-3-(4-benzylpiperazin-l-yl-
methyl)piperidine-1-carboxylic acid tert-butyl ester
The crude obtained in step 3.1 is dissolved in 75 ml of
5 toluene. 12.16 g of benzylpiperazine are added, and the reaction medium is sealed and then heated at 150°C for 5 hours. After a return to AT, the medium is diluted in an ether/pentane mixture (1/1), and washed twice with a saturated NaHCO3 solution, twice in water, and then with
10 a saturated NaC1 solution. After drying over MgSO4 and evaporation, the crude is purified by flash chromatography on silica gel, to give 5.73 g of the expected solid.
MH+ = 374 at t = 5.26 min
15
3.3. Preparation of (R)-1-benzy1-4-(1-methylpiperidin¬3-ylmethyl)piperazine
5 g of the compound obtained in step 3.2 dissolved in
20 45 ml of THF are added to a solution of 1 g of LiA1H4 in 45 ml of THF cooled to 0°C. The medium is stirred at AT for two hours and then cooled to 0°C. 0.96 ml of water and then 3 ml of 5M NaOH are added, the medium is then filtered, and the solid is rinsed with ether. The
25 filtrate is evaporated, taken up in ether, and washed twice with a saturated NaHCO3 solution and then with a saturated NaC1 solution. After drying over MgSO4 and evaporation, 3.5 g of the desired compound are recovered.
30 MH+ = 288 at t = 5.68 min
 
3.4.    Preparation    of    (R)-1-(1-methylpiperidin-3-yl-
methyl)piperazine
A solution of 3.46 g of the compound obtained in step
5 3.3, in 100 ml of methanol, is hydrogenated in the presence of 1.9 g of wet 10% Pd/C under 800 kPa of hydrogen pressure at 40°C for 3 hours. The medium is filtered and then evaporated, to give 2.26 g of a colourless oil.
10
3.5. Preparation of (R)-N-[4-(5-cyclohexy1-2-methoxy-
phenyl)thiazo1-2-y1]-N'-[4-(1-methylpiperidin-3-yl-methyl)piperazin-l-yl]urea
15 The synthesis of this compound is carried out according to the procedure described in Example 1, from 4-(5- cyclohexy1-2-methoxypheny1)-1,3-thiazol-2-amine
described in preparation 1.3 and from the compound obtained in step 3.4.
    20 Mp = 108°C; [a]r)25 = -27°    = 1.05; Me0H)
Example 4: (Compound No. 70) N-[4-(5-cyclohexy1-2- methoxyphenyl)thiazol-2-y1]-N'-[4-(1-isopropyl-piperidin-3-yl)piperazin-l-yl]urea
25 Compound of formula (I) in which:
R1 = 2-OCH3; R2 = 5-CyHex; R3 = 4-(1-isopropylpiperidin¬3-y1); a = 2
 
 
4.1.    Preparation    of    4-(1-benzylpiperidin-3-y1)-
piperazine-l-carboxylic acid tert-butyl ester
20 ml of a 10% sodium hydroxide solution are added to a
5 suspension of 9.96 g of 1-benzy1-3-piperidone monohydrochloride hydrate in suspension in 200 ml of DCM. The medium is stirred, and the organic phase is separated by settling out and then washed with a saturated NaC1 solution. After drying over MgSO4, the
10 organic phase is concentrated. The gum obtained is taken up in 180 ml of DCE, 10.1 g of Boc-piperazine and then 15.9 g of NaBH(OAc)3 are added and the medium is stirred at AT for 12 h. The medium is concentrated and then taken up in EtOAc. The organic phase is washed
15 twice with a saturated NaHCO3 solution, and then with a saturated NaC1 solution. After drying over MgSO4, the organic phase is concentrated, to give 18.63 g of the expected product.
Mp = 103°C.
 
4.2.    Preparation    of    1-(1-benzylpiperidin-3-y1)-
piperazine
30 g of TFA are added to a solution of 9.2 g of the
5 compound obtained in step 4.1, in 85 ml of DCM. The medium is stirred at AT for 5 h, and then concentrated. The crude obtained is taken up in DCM and then washed 4 times with a 2M sodium hydroxide solution. The organic phase is washed with a saturated NaCl solution. After
10 drying over MgSO4, the organic phase is concentrated, to give 6.32 g of the expected product.
1H NMR: 5 (ppm) = 7.28 (salt, 5H), 3.43 (salt, 2H), 2.88 (d, 1H), 2.70 (d, 1H), 2.64 (m, 4H), 2.43-2.22 (m, 5H), 1.85-1.58 (m, 4H), 1.39 (ddd, 1H), 1.15 (ddd, 1H).
15
4.3.    Preparation    of    N-[4-(5-cyclohexy1-2-methoxy-
phenyl)thiazol-2-y1]-N'-[4-(1-benzylpiperidin-3-y1)-  piperazin-l-yl]urea (Compound No. 68)
Compound of general formula (I) in which:
20 R1 = 2-OCH3; R2 = 5-CyHex; R3 = 4-(1-benzylpiperidin-3- yl); a = 2
The procedure is identical to that described in Example
1,    using    the    4-(5-cyclohexy1-2-methoxypheny1)-1,3-
25 thiazol-2-amine described in preparation 1.3 and the compound obtained in step 4.2.
Mp = 90°C
4.4.    Preparation    of    N-[4-(5-cyclohexyl-2-methoxy-
30 phenyl)thiazol-2-y1]-N'-[4-piperidin-3-ylpiperazin-l-yl]urea (Compound No. 69)
Compound of the formula (I) in which:
R1 = 2-OCH3; R2 = 5-CyHex; R3 = 4-(piperidin-3-y1); a = 2
 
1.26 g of chloroethyl chloroformate are added, at 0°C, to a solution of 1.69 g of the compound obtained in step 4.3, in 10 ml of DCE. The medium is returned to AT and is then refluxed for 45 min. The medium is
5 evaporated and then taken up in 10 ml of NeOH and refluxed for 1 h. The crude is filtered, and the solid is rinsed with ether and dried, to give 1.27 g of the
expected compound in the form of a trihydrochloride. Mp = 240°C.
10 MH+ = 484 at 6.81 min
4.5.    Preparation    of    N-[4-(5-cyclohexy1-2-methoxy-
phenyl)thiazol-2-y1]-N'-[4-(1-isopropylpiperidin-3-  yl)piperazin-1-yl]urea (Compound No. 70)
15 Compound of formula (I) in which:
R1 = 2-OCH3; R2 = 5-CyHex; R3 = 4-(1-isopropylpiperidin¬3-yl); a = 2
0.05 ml of acetone followed by 0.15 g of NaBH(OAc)3 are
20 added to a solution of 0.2 g of the compound obtained in step 4.4, in 1.2 ml of DCE, and the medium is stirred at AT for 3 h. 0.1 ml of Et3N and then 0.1 mg of NaBH(OAc)3 are added. The medium is stirred at AT for 12 h. The medium is concentrated and then taken up in
25 EtOAc. The organic phase is washed twice with a saturated NaHCO3 solution, and then with a saturated NaC1 solution. After drying over MgSO4, the organic phase is concentrated and then purified by flash chromatography to give 0.11 g of the expected product.
30 Mp = 130°C
MH+ = 526 at t = 7.06 min
 
Example 5: (Compound No. 74) N-[4-(S-cyclohexy1-2- methoxyphenyl)thiazol-2-y1]-N'-[4-(1-methylpiperidine¬2-carbonyl)piperazin-1-yl]urea
Compound of formula (I) in which:
5 R1 = 2-OCH3; R2 = 5-CyHex; R3 = 4-(1-methylpiperidine-2- carbonyl); a = 2
 
5.1. Preparation of 4-(1-benzyloxycarbonylpiperidine-2-  carbonyl)piperazine-l-carboxylic acid tert-butyl ester
10
26.6 g of BOP,    13.6 g of 1-(carbobenzyloxy)-2-
piperidinecarboxylic acid and then 11.9 ml of
triethylamine are added, at 0°C, to a solution of 8 g
of 1-Boc-piperazine in 80 ml of acetonitrile. The
15 medium is stirred at AT for 12 hours and then concentrated. The medium is taken up in EtOAc, and washed three times with a saturated Na2CO3 solution and then with a saturated NaC1 solution. After drying over MgSO4 and evaporation, 35.45 g of reaction crude are
20 recovered. It is taken up in DCM and then washed twice with 5M sodium hydroxide, and with a saturated NaC1 solution, and then dried over MgSO4. After evaporation, the solid is triturated in TBME, filtered, rinsed with TBME, and then dried, to give 17.93 g of the desired
25 compound.
Mp = 102°C
 
5.2.    Preparation    of    4-(piperidine-2-carbony1)-
piperazine-l-carboxylic acid tert-butyl ester
3.9 ml of cyclohexadiene and then 1.3 g of 10% Pd/C
5 with a 50% water content are added, under an inert atmosphere, to a solution of 1.79 g of the compound obtained in step 5.1, in 14 ml of EtOH. The medium is stirred at AT for 24 hours and then filtered. The filtrate is evaporated, to give 1.02 g of the desired
10 compound.
5.3. Preparation of 4-(1-methylpiperidine-2-carbony1)-  piperazine-1-carboxylic acid tert-butyl ester
15 0.54 ml of 37% aqueous formaldehyde and then 1.41 g of NaBH(OAc)3 are added to a solution of 0.99 g of the compound obtained in step 5.2, in 11 ml of DCE, and the medium is stirred at AT for 12 h. The medium is diluted in DCM and filtered through cotton wool. The organic
20 phase is washed twice with a saturated NaHCO3 solution, and then with a saturated NaC1 solution. After drying over MgSO4 and evaporation of the solvents, 0.84 g of the expected product is recovered.
25 5.4. Preparation of (1-methylpiperidin-2-yl)piperazin¬1-ylmethanone
2 ml of TFA are added to a solution of 0.84 g of the
compound obtained in step 5.3, in 2 ml of DCM. The
30 medium is stirred at AT for 6 h. The medium is
evaporated, taken up several times in DCM, and
evaporated so as to entrain the TFA. The medium is
taken up in DCM and then treated with a 10% NH4OH
 
solution. The organic phase is dried over MgSO4 and then
evaporated, to give 0.15 g of the expected product.
5.5.    Preparation    of    N-[4-(5-cyclohexy1-2-methoxy-
5 phenyl)thiazol-2-y1]-N'-[4-(1-methylpiperidine-2-  carbonyl)piperazin-1-yl]urea
The procedure is identical to that described in Example
1,    using    the    4-(5-cyclohexy1-2-methoxypheny1)-1,3-
10 thiazol-2-amine described in preparation 1.3 and the product obtained in step 5.4.
Mp = 135°C
Example 6: (Compound No. 88) N-[4-(5-cyclohexy1-2- 15 methoxyphenyl)thiazol-2-y1]-N'-[4-(1-methylpiperidin-2- ylmethyl)piperazin-l-yl]urea
Compound of formula (I) in which:
R1 = 2-0CH3; R2 = 5-CyHex; R3 = 4-(1-methylpiperidin-2- ylmethyl); a = 2
 
20
6.1. Preparation of 4-(1-benzyloxycarbonylpiperidin-2-  ylmethyl)piperazine-l-carboxylic acid tert-butyl ester
162 ml of a molar solution of borane in THF are added,
25 at 0°C, to a solution of 14 g of the compound prepared
in step 5.1, in 50 ml of THF, over a period of 30 min.
The medium is stirred at AT for 24 hours and then
hydrolysed by the addition of water at 0°C. After
dilution in EtOAc, the medium is washed three times
 
with a saturated Na2CO3 solution, and then with a saturated NaC1 solution. After drying over MgSO4 and evaporation, 12.6 g of the expected compound are recovered.
5
6.2. Preparation of 4-piperidin-2-ylmethylpiperazine-1-  carboxylic acid tert-butyl ester
14.5 ml of cyclohexadiene followed by 3.3 g of 10% Pd/C
10 having a 50% water content are added, under an inert atmosphere, to a solution of 6.43 g of the compound obtained in step 6.1, in 50 ml of EtOH. The medium is stirred at AT for 48 hours and then filtered. The filtrate is evaporated, to give 3.63 g of the desired
15 compound.
6.3. Preparation of 4-(1-methylpiperidin-2-ylmethyl)- piperazine-l-carboxylic acid tert-butyl ester
20 1.91 ml of 37% aqueous formaldehyde and a few beads of 4A molecular sieve, followed by 5 g of NaBH(OAc)3, are added to a solution of 3.34 g of the compound prepared in step 6.2, in 40 ml of DCE, and the medium is stirred at AT for 48 h. The medium is diluted in DCM, and
25 filtered through cotton wool. The organic phase is washed twice with a saturated NaHCO3 solution, and then with a saturated NaCl solution. After drying over MgSO4 and evaporation of the solvents, 3.28 g of the expected product are recovered.
30
 
6.4. Preparation of 1-(1-methylpiperidin-2-ylmethyl)-  piperazine
1 ml of a 4M solution of HC1 in dioxane is added to a
5 solution of 3.28 g of the compound obtained in step 6.3, in 1 ml of dioxane. The medium is stirred at AT for 48 h. The medium is filtered, and the solid is rinsed with ether and then dried, to give 2.9 g of the desired compound.
10
6.5.    Preparation    of    N-[4-(5-cyclohexy1-2-methoxy-
phenyl)thiazol-2-y1]-N'-[4-(1-methylpiperidin-2-yl-methyl)piperazin-l-yl]urea
15 The procedure is identical to that described in Example 1, using the 4-(5-cyclohexy1-2-methoxypheny1)-1,3- thiazol-2-amine described in preparation 1.3 and the compound obtained in step 6.4.
Mp = 103°C
 
 
Table II

No.    R1    R2    R3    Y    a    Salt    M p(°C)
M
1    -OCH3    -O(CH2)2CH3    —\--no
\__/    H    2    -    144 °C
2    -OCH3    -O(CH2)2CH3    \A
rTh
(, o    H    2    -    96°C
3    -OCH3    -(CH2)2CH3    \    r—No
\,    H    2    -    66°C
 
Table II (continued)

No.    Ri    R2    R3    Y    a    Salt    M p (°C)
M
4    -OCH3    ..(c H2)2C H3    ..,X 1---)
,1
(\s„-o    H    2    -    90°C
5    -OCH3    —0    —\--n
\___ Jo    H    2    -    66°C
6    -OCH3    -(CH2)3CH3    rir-Ni
( \,.- o    H    2    -    133°C
7    -OCH3    -(CH2)3CH3    r-N
—\--N \__io        2    -    45°C
8    -OCH3        \A 1---)
1 4
.,.,,..o    H    2    -    113°C
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    hilp (°C)
M
9    -OCH3    -(CH2)2CH3    /---\
..,,,,,,,,,,,,,,,\    %    H    2    HCI    229°C
10    -OCH3    -(CH2)2CH3    /—\
.„.....z...„,„,\_20        3    HCI    234°C
11    -OCH3    -(CH2)2CH3    ...s,,,,,, ri\    )    H    2    HCI    202°C
12    -OCH3    -(CH2)2C H3    \/\/ 0    H    2    HCI    199°C
13    -OCH3    -(CH2)2CH3    -.../CiN    H    CH3
2    HCI    230°C
14    -OCH3    -(CH2)2C H3    r61-13
V\/' l'k--CH3    H    2    HCI    145°C
 
Table II (continued)

No.    Ri    R2    R3    Y    a    Salt    Mp (°C)
M
15    -OCH3    -(CH2)2CH3    ?I-13
-r\,r'L CH,    H    2    HCI    245°C
16    -OCH3    -(CH2)2CH3    ?I-13
..„-\7.- N,cH3    H    2    HCI    239°C
17    -OCH3    -(CH2)2C H3    ■,,,,/ \ .,./ 0    H    3    HCI    223°C
18    -OCH3    -(CH2)2CH3    0    H    2    HCI    245°C
19    -OCH3    -(CH2)2CH3    a
0    H    2    HCI    180°C
 
Table II (continued)

No.    R,    R2    R3    Y    a    Salt    M p (*C)
M
20    -OCH3    -(CH2)2CH3    a    H    2    HCI    181°C
21    -OCH3    -(CH2)2CH3    /    H    2    HCI    209°C
22    -OCH3    -(CH2)2CH3        H    2    HCI    200°C
23    -OCH3    -(CH2)2CH3        H    2    HCI    242°C
24    -OCH3    -(CH2)2CH3    '''Ck    H    CH3
2    HCI    248°C
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    M p (°C)
M
25    -OCH3    --a    7.`,.7 0    H    2    -    114°C
26    -OCH3    -(CH2)3CH3    ..„/"....„." 0    H    2    -    65°C
27    -OCH3    -O(CH2)2CH3    V\/    H    2    -    70°C
28    -OCH3    -(CH2)2CH3    N    H    2    -    82°C
29    -OCH3        /"N/ 0    H    2    HCI    MH+ =
534 at 6.14
min
        F
F    F                   
 
Table II (continued)

NO.    Ri    R2    R3    Y    a    Salt    M 101 (°C)
M
30    -OCH3    —0    7-....,.,,-- 0    H    2    -    MH+ =
498
at 6.52
min
31    -OCH3    -(CH2)2CH3    Y' 0
o    H    2    -    89°C
32    -OCH3    -(CH2)2CH3    H
t0--ircii3
Nl
0
0    H    3    -    MH+ =
543
at 5.85
min
33    -OCH3    -(CH2)2CH3    H
../.\-/- a' Nr.s..CH3    H    2    -    MH+ =
501
at 5.03
min
 
Table II (continued)

No.    Ri    R2    R3    Y    a    Salt    Mp(°C)
M
34    -OCH3    -(CH2)2CH3    o 0    H    3    -    MH+ =
486
at 6.04
min
35    -OCH3    -(CH2)2CH3    H
.7    N    H,    H    3    HCI    MH+ =
515
at 8.77
min
36    -OCH3    -(CH2)2CH 3    7,,,..,/ 0    F    2    -    63°C
37    -OCH3    -(CH2)2CH3         110    H    2    -    63°C
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    M p (°c)
M
38    -OCH3    -(C H2)5C H3    /N/°    H    2    HCI    MH+ = 500
at 6.99 min
39    -OCH2CH3    -CH2CH3    ■,,,...„----.,_ NV-Ni
\         H    2    -    96°C
40    -OCH2CH3    -(CH2)3CH 3    - \ ,......./ `..., ,,
NrNi    H    2    -    130°C
41    -OCH2CH3        ---...„..----....,
NC    H    2    -    89°C
                           
42    -OCH3    -CH2CH3    ,-,,,,....„----,,,,
NC?    H    2    -    100°C
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    M p (°C)
M
43    -OCH3        N __.
C H3    H    2    -    106°C
                           
                           
                           
44    -OCH3    0---    --.....„......„..---„,,...„, N ,,_
C H3    H    2    -    98°C
45    -OCH3    -(CH2)3CH3    -....,.......„,....--...    N ,,
C H 3    H    2    -    90°C
46    -OCH3    -(CH2)3CH3    -...,    N
- C H3    H    2    -    69°C
 
Table II (continued)

No.    R1    R2    R3    V    a    Salt    M p (°C)
M
47    -OCH3    0—    IN
-C H3    H    2    -    103°C
48    -OCH3        01\1,
\C H3    H    2    -    98°C
                           
49    -OCH2CH3        N    H    2    -    109°C
                           
                           
50    -OCH2CH3        N ,._
-C H3    H    2    -    108°C
                           
51    -OCH2CH3        ----.,--Th
\/N „_
-CH3    H    2        106°C
                           
                           
                           
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    Mp (°C)
M
52    -OCH2C H3        -NC H 3    H    2    -    96°C
53    -OCH2CH3    0--    ,,,,.../ "...,, ...,
NrNi    H    2    -     75°C
54    -OCH2CH3    -(CH2)3CH3    .....'CIN ,_
- C H3    H    2    -    140°C
55    -OCH3        -------------ON.,
-CH3    H    2    -    102°C
56    -OCH2CH3    -(CH2)3C 113    -......„.„.„....0N,_
-CH3    H    2    -    91°C
 
Table H (continued)

No.    R1    R2    R3    Y    a    Salt    M p (°C)
M
57    -OCH2CH3        -NCH3    H    2    -    110°C
                           
                           
                           
58    -OCH3        ....,,s.,..--...,,
N\V    F    2    HCI    MH+= 516 'at 6.79 min
                           
                           
                           
59    -OCH3        --..„,„ N , C H3
-     F    2    HCI    MH+= 515 at 6.01 min
                           
                           
                           
60    -OCH3            F    2    HCI    MH+= 532 at 6.91 min
            N/    \O               
                           
                           
                           
 
Table II (continued)

NO.    R1    R2    R3    Y    a    Salt    M p (°C)
M
61    -OCH3        3    H    2    -    118°C
                           
62    -OCH3    -(CH2)3CH3    N    H    2    -    84°C
63    -OCH3    0-    N
11101    H    2    -    79°C
64    -OCH3    F    F    -------'CiN ....._
-CH3    H    2    -    97°C
        F
F    F                   
65    -OCH3    F    F    N .,_
-CH3    H    2    -    172°C
        F
F    F                   
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    mp (°C)
M
66    -OCH3         ,- --Cy C H 3    H    2    -    107°C
                           
                           
                           
67    -OCH3    c>--    ---/'---- N
_,...,,)    1-1    H    2    -    83°C
68    -OCH3    0--
-...„.... _.„---..,    *    H    2    -    90°C
69    -OCH3        H
------0    H    2    3 HCI    240°C
                           
                           
                           
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    m p CC)
M
70    -OCH3        CH3
 CI . CH3    H    2    -    130°C
                           
71    -OCH3    0--    0
C H 3
04    CH3    H    2    -    127°C
72    -OCH3    0--    0
------01    0\
 CH3     H    2    -    125°C
73    -OCH3    o--    0    H        -    122°C
 
Table 1I (continued)

No.    Fil    R2    R3    Y    a    Salt    Mp (°C)
M
            „,„.,--,,,               
74    -OCH3    0--    Yr■'..-    H    2    -    135°C
            0    CH3               
75    -OCH3                2    -    107°C
        0—    NCH3
(5)               
76    -OCH3            H    2    -    108°C
                           
            -...,.....0,0 -...„..._,,,N......,               
            CH    (R)               
                           
            CH               
            I    3               
77            N               
    -OCH3    -(C H2)3C H3    4,C;    H    2    -    85°C
            (R)               
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    MP (CC)
M
78    -OCH3        C)---
CH
I    3
-,'N`.
    `'',..•/\..,/    (R)    H    2    -    94°C
79    -OCH3    -(CH2)5CH3    CH
I    3
'-..,
/N'-..,
W    H    2    -    68°C
80    -OCH2CH3    -(CH2)5CH3    CH3 I
----N
 -...
W    H    2    -    65°C
81    -OCH2CH3    -(CH2)3CH3    CH-
4
N
0    (R)    H    2    -    75°C
 
Table II (continued)

No.    R1    R2    R3    V    a    Salt    M p (°C)
M
82    -OCH3    H3C
).
H3C    C H3 I
..7 N ',..
'"------"--../    H    2    -    85°C
83    -OCH2CH3    -(CH2)2CH3    CH
I    3
..--- N --..
'---..-----------    H    2    -    74°C
84    -OCH2CH3    0    CH
I    3
/N\
(R)    H    2    -    92°C
                           
85    -O(CH2)2CH3    -CH2CH3    CH
I    3
N;    H    2    -    73°C
 
Table II (continued)

No.    Ri    R2    R3    Y    a    Salt    m p (°C)
M
86    -OCH3    -CH2CH3    CH
I    3
N -.    H    2    -    86°C
87    -OCH2CH3        CH
i    3
.rN
    s'-,...../    (R)    H    2    -    98°C, 103°C
                           
                           
                           
88    -OCH3    o--    ,,,,,-...,,
N CH3    H    2    -    103°C
89    -OCH3        /
N
H    H    2    -    121°C
                           
                           
 
Table II (continued),

NO.    R1    R2    R3    Y    a    Salt    m p (°C)
M
90    -OCH3    0--
.,„/NN...    0    ,CH,    N
H    2    -    119°C
91    -OCH3    -CH3    C
NH3
N
,--    --.    H    2    -    95°C
92    -OCH3            H    2    -    85°C
                           
            I.               
                           
93    -OCH3        3
.\/\/Ny    CH3
0    CH3    H    2    -    125°C
                           
                           
                           
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    Mp (°C)
M
94    -OCH3        0

_kcH3
H3C    CH3    N l H    3    -    112°C
                           
                           
                           
95    -OCH3        \■-
CH3 (S)    H    N
2    -    101°C
                           
                           
                           
96    -OCH3            H    2
NH    -    215°C
                           
            ----               
                           
97    -OCH3    0—    N—CH3    H    2    -    103°C
98    -OCH3        CH3    ON,
H    2    -    106°C
                           
                           
                           
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    M p (°C)
M
99    -OCH3    0.--     NH    H    2    -    128°C
100    -OCH3        ,    H    3    -    88°C
                           
                           
                           
101    -OCH3        \■■■‘0
"
CH3
(S)    H    2    -    122°C
                           
                           
                           
102    -OCH3        0
D A CH3    H    2    -    146°C
                           
                           
                           
103    -OCH3    0--    O    H    2    -    132°C
 
Table II (continued)

No.    Ri    R2    R3    Y    a    Salt    M p (°C)
M    Other
analysis
104    -OCH3        O
9
S,
N- ‘' CH
0    3    H    2    -    132°C   
                               
                               
                               
105    -OCH3            H    rl AV
2    -    119°C    -
                               
                               
                               
106    -OCH3        O
CH ,
CH,
(S)    H    2    -    118°C    -
                               
                               
                               
107    -OCH3        O
N
I    H    2    -    -    MH+ = 590 at 7.52 min
                               
                               
                               
108    -OCH3        0
NO    H    2    -    -    C :63.17
H : N : 13.51
                               
                               
                               
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    M p (°C)
M    Other
analysis
109    -OCH2CH3            H    2    -    111°C    -
                               
                               
                               
110    -OCH2CH3        O    H    2        113°C    -
                               
                               
                               
111    -OCH3        0
D-RyCH3
CH,
-    (R)    H    2    -    98°C    acs = -6.2°
c = 1.0 M Me0H
                               
                               
                               
112    -OCH3        vo    0. 0
H Cni
3    ,..,    (s)    H    2    -    158°C    -
                               
                               
                               
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    m p (°C)
M
113    -OCH3        I
1
0    O    (S)    H    2    -    158°C
                           
                           
                           
114    -OCH3        o `s    y osCH3
0    (S)        2    -    125°C
                           
                           
                           
115    -OCH3        0‘    CH
Y3
0
(S)    H    2    -    157°C
                           
                           
116    -OCH3    o--    --)...
0    N''')
c0    H    2    -    119°C
 
Table II (continued)

No.    R1    R2    R3    Y    a    Salt    Mp' (°C)
M
117    -OCH3        I.1    H    2    -    81°C
118    -OCH3    0-    N•-...00N-,..."‘".F
(S)    H    2    -    91°C
119    -OCH3    0--    y'- 0
0            -    117°C
120    -OCH3        0 ,,,,./,-.1,,,,,.N    H    2    -    78°C
 
The compounds according to the invention were subjected to pharmacological assays in order to determine their modulatory effect on the activity of chemokine receptors.
5
Chemokines are low molecular weight proteins that belong to the pro-inflammatory cytokine family and are involved in leukocyte and endothelial cell chemotaxis. Chemokines control many biological processes and are
10 associated with inflammatory disorders that appear during states of stress, during injuries or during infections; modulating the effect of chemokines makes it possible to prevent or treat pathologies such as asthma, arthritis, allergies, autoimmune diseases,
15 atherosclerosis or angiogenesis (C.D. Paavola et al., J. Biol. Chem., 1998, 273, (50), 33157-33165).
Among    the    chemokines,    hMCP-1    (human    monocyte
chemotactic protein) which belongs to the CC chemokine 20 group and which is a natural agonist of the CCR2b receptor, is distinguished.
The inhibitory activity of the compounds according to
the invention on cells expressing the human CCR2b
25 receptor was measured. The concentration of natural agonist hMCP-1 that inhibits 50% (IC50) of the activity of the CCR2b receptor is 0.57 nM. The compounds according to the invention exhibit an IC50 that is generally less than 0.1 pM.
30 For example, Compound No. 14 exhibited an IC50 of 0.0033 pM;
Compound No. 28 exhibited an IC50 of 0.028 pM;
Compound No. 55 exhibited an IC50 of 0.014 pM.
 
The inhibition of chemotaxis was also measured on human THP-1 monocyte cells (sold by DSMZ - Germany), using a technique adapted from that described by A. Albini et al., Cancer Res., 1987, 47, 3239-3245. Under these
5 conditions, hMCP-1 exhibits an IC50 of 6 nM. The compounds according to the invention exhibit an ICso that is generally less than 1 pM.
The inhibition of chemotaxis by the compounds according
10 to the invention is a sign of their antagonistic activity on chemokine receptors, and in particular the CCR2b receptor.
It therefore appears that the compounds according to 15 the invention are antagonist of the effect of chemokines, in particular of hMCP-1.
The inhibitory activity of the compounds according to
the invention was also measured on PBMCs (peripheral
20 blood mononuclear cells) infected with the HIV-1 Bal virus, according to a technique adapted from that described by V. Dolle et al., J. Med. Chem., 2000, 43, 3949, 3962. According to this technique, the PBMCs are infected with HIV-1 Bal and the compounds to be tested
25 are then added to the culture medium for 5 days. At the end of this exposure, the amount of reverse transcriptase in the supernatant is measured, which correlates with the level of viral replication in the cells.
30
Under these conditions, AZT, a reference molecule which
inhibits viral replication, exhibits an IC50 of less
than 1 pM. Compounds according to the invention also
 
exhibit IC50 values of less than 1 pM. For example, Compound No. 30 showed an IC50 of 0.6 pM.
The compounds according to the invention can therefore
5 be used for preparing medicinal products, in particular medicinal products that are agonists of the effect of chemokines.
Thus, according to another of its aspects, a subject of
10 the present invention is medicinal products which comprise a compound of formula (I) or an addition salt of the latter with a pharmaceutically acceptable acid, or else a hydrate or a solvate.
15 These    medicinal    products    find    their    use    in
therapeutics, in particular in the prevention and treatment of various pathologies, such as:
- acute and chronic immunoinflammatory diseases and
syndromes, such as atherosclerosis, restenoses, chronic
20 pulmonary diseases, in particular COPD (chronic obstructive pulmonary disease); respiratory distress syndrome; bronchial hyperactivity; colitis; silicosis; fibrous pathologies, pulmonary fibroses, cystic
fibroses;    viral    or    bacterial    infections,    AIDS,
25 meningitis, malaria, leprosy, tuberculosis, herpes, cytomegalovirus infections; septic shocks, septicaemia, endotoxic shocks; transplant rejections; bone
pathologies such as osteoporosis,    osteoarthritis;
conjunctivitis; atypical or contact dermatitis; eczema;
30 glomerulonephritis; pancreatitis; ulcerative colitis, autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, amyotrophic lateral sclerosis, Crohn's disease, lupus erythematosus, scleroderma,
 
psoriasis; Parkinson's disease; Alzheimer's disease; diabetes; cachexia; obesity;
-    the treatment of pain, in particular neuropathic and inflammatory pain;
5 - allergic diseases such as allergic respiratory diseases, asthma, rhinitis, pulmonary hyper-senstitivity, delayed hypersensitivity;
-    diseases and disorders in which angiogenic processes are    involved,    such    as    cancers    (intratumoral
10 angiogenesis), retinal diseases (age-related macular degeneration: ARMD);
-    cardiac pathologies: haemodynamic shock; cardiac ischaemias;    post-ischaemic    reperfusion    attacks;
myocardial infarction,    coronary thrombosis,    heart
15 failure, angina pectoris.
According to another of its aspects, the present
invention relates to pharmaceutical compositions
comprising, as active principle, a compound according
20 to the invention. These pharmaceutical compositions contain an effective dose of at least one compound according to the invention, or a pharmaceutically acceptable salt, or a hydrate or solvate of said compound, and also at least one pharmaceutically
25 acceptable excipient.
Said excipients    are    chosen,    according    to    the
pharmaceutical form and the method of administration desired, from the usual excipients that are known to 30 those skilled in the art.
In the pharmaceutical compositions of the present invention    for    oral,    sublingual,    subcutaneous,
 
intramuscular, intravenous, topical, local, intra-tracheal, intranasal, transdermal or rectal administration, the active principle of formula (I) above, or its possible salt, solvate or hydrate, can be
5 administered in unit administration form, as a mixture with conventional pharmaceutical excipients, to animals and to human beings for the prophylaxis or the treatment of the disorders or of the diseases above.
10 The suitable unit administration forms comprise oral forms such as tablets, soft or hard gelatin capsules, powders, granules and oral solutions or suspensions, sublingual, buccal, intratracheal, intraocular and intranasal administration forms, forms for
15 administration by inhalation, topical, transdermal, subcutaneous, intramuscular or intravenous administration forms, rectal administration forms, and implants. For topical application, the compounds according to the invention can be used in creams, gels,
20 ointments or lotions.
By way of example, a unit administration form of a compound according to the invention in the form of a tablet can comprise the following constituents:
25 Compound according to the invention    50.0 mg
Mannitol    223.75 mg
Sodium croscaramellose    6.0 mg
Corn starch    15.0 mg
Hydroxypropylmethylcellulose    2.25 mg
30 Magnesium stearate    3.0 mg
When given orally, the dose of active principle
administered per day can reach 0.1 to 1000 mg/kg, taken
 
in one or more doses.
There may be specific cases where higher or lower
dosages are appropriate; such dosages do not depart
5 from the context of the invention. According to the usual practice, the dosage appropriate for each patient is determined by the physician according to the method of administration, and the weight and response of said patient.
10
According to another of its aspects, the present invention also relates to a method of treating the pathologies indicated above, which comprises the administration of an effective dose of a compound
15 according to the invention, or one of its pharmaceutically acceptable salts or hydrates or solvates, to a patient.
 
CLAIMS
1.    Compound of formula (I) below:
 
(I)
—N
in which
5 -(i)    R1 is selected from the group consisting of H,
halogen,    (C1-C9) alkyl,    trifluoro (C1-C4) alkyl,    -OH,
-    0- (C1-C8) alkyl,    -0-trifluoro (C1-C8) alkyl,    -0-
(C3-C10)cycloalkyl(C1-C8)alkyl, -0- (C3-C10) cycloalkyl, -0- CH2-CH=CH2 and (C1-C4)alkylthio;
10 -(ii)    R2 is selected from the group consisting of H,
halogen,    -OH,    (C1-C8) alkyl,    trifluoro (C1-C4) alkyl,
perfluoro (C1-C4) alkyl,    (C3-C10) cycloalkyl,
C8) alkyl,    -0- (C3-C10) cycloalkyl (C1-C8) alkyl,    -0- (C1-
 -0- (C3-

C10) cycloalkyl, -O-CH2-CH=CH2 and (C3-C8) cycloalkyl (C1¬ 15 C8)alkyl;
-    (iii) Y represents a hydrogen atom or a halogen;
-    (iv)    R3 represents:
al) a group of formula -(CH2)p-A
20 in which p represents 0, 1, 2, 3 or 4, and:
-    when p represents 2, 3 or 4, A represents a group of formula:
 

 
-    NR4R5,
 
in which R6 is selected from the group consisting of H, F,    (C1-C4)alkyl,    -(CH2)n0H,    -(CH2)n0(01-C4)alkyl    and
-    (CH2),INR4R5, where n represents 0, 1 or 2, and R4 and R5 represent, independently of one another, a hydrogen
5 atom, or a (C1-08) alkyl, -CO (01-04) alkyl or -00-0- (C1-C8)alkyl group;
-    or, when p represents 1, 2, 3 or 4, A represents a group of formula:
17    17    17
/'
trO,    —N ,R7
or
10 in which R7 is selected from the group consisting of H, (01-08) alkyl, -00- (C1-C8) alkyl, benzyl, -00-0- (Ci¬C8)alkyl, -00-0-benzyl, -CO-phenyl, -CO-heteroaryl, -CO-(C3-010) cycloalkyl, -S02-(01-08)alkyl, -502- (C3¬ 08)cycloalkyl and -S02-heteroaryl;
15 - or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
 

 
said group being optionally substituted with a (C1-04)- alkyl group;
a2) a group of formula -(CH2)p-CO-A in which p represents 1, 2, 3 or 4,
-    A represents a group of formula:
 
-    NR4R5r in which R4, R5 and R6 are as defined above;
5 a3) a group of formula -CO(CH2)p-A
in which p represents 0, 1, 2, 3 or 4
-    when p represents 1, 2, 3 or 4, A represents a group of formula:
—N 0
/    '
R6         —N    Rs    —    N
1 -1—R6    ,    or

10 -NR4R5,
in which R4, R5 and R6 are as defined above;
-    or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
     RR
N7    N7
0R
7
4),    ),or—E-T/ 

15 in which R7 is as defined above;
-    or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
 

 
said group being optionally substituted with a (C1-C4)- alkyl group;
 
a4) a group -B
in which B represents a group of formula:
 

 
in which R7 is as defined above;
-(v)    a represents 2 or 3;
in the form of a base or of an addition salt with an acid, and also in the form of hydrates or of solvates.
2.    Compound according to Claim 1, of formula (I.a)
10 below:
 

 
in which:
R1, R2, R3 and Y are as defined above,
in the form of a base or of an addition salt with an 15 acid, and also in the form of hydrates or of solvates.
3.    Compound according to Claim 1, of formula (I.b)
below:
 
 
in which RI, R2, Y, p and A are as defined above,
in the form of a base or of an addition salt with an acid, and also in the form of hydrates or of solvates.
5 4.    Compound according to Claim 1, of formula (I.c)
below:
 

 
in which R1, R2, Y and B are as defined above,
in the form of a base or of an addition salt with an 10 acid, and also in the form of hydrates or of solvates.
5.    Compounds according to either one of Claims 1 and
2, chosen from:
•    (R)-N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]- 15 N'-[4-(1-methylpiperidin-3-ylmethyl)piperazin-l-y1]- urea,
•    N-[4-(2-methoxy-5-propoxyphenyl)thiazol-2-y1]-Nr¬[4-(2-morpholin-4-ylethyl)piperazin-l-yl]urea,
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-W-[4- 20 (3-piperidin-l-ylpropyl)piperazin-l-yl]urea,
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- (2-dimethylaminoethyl)piperazin-1-yl]urea, N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-Nr-[4-(2- oxo-2-pyrrolidin-l-ylethyl)piperazin-l-yl]urea,
25 •    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-W-[4-
(2-thiophen-2-ylethyl)piperazin-l-yl]urea,
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4-
 
[2-(tetrahydrofuran-2-yl)ethyl]piperazin-l-yl]urea,
N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- (2-pyrrolidin-l-ylacetyl)piperazin-1-yl]urea,
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- 5 [2-(3-ethylaminopyrrolidin-l-yflethyl]piperazin-l-y1]- urea,
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(1-methylpiperidin-4-yl)piperazin-l-yl]urea,
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-W¬10 [4-(1-benzylpiperidin-3-yl)piperazin-l-yl]urea,
•    N-[4-(2-methoxy-5-propylphenyl)thiazol-2-y1]-N'-[4- (2-pyridin-4-ylethyl)piperazin-l-yl]urea,
•    N-[4-(2-methoxy-5-pentafluoroethylphenyl)thiazol-2- y1]-W-[4-(2-pyrrolidin-l-ylethyl)piperazin-1-yl]urea,
15 •    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-W-
[4-(1-isopropylpiperidin-3-yl)piperazin-l-yl]urea,
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-W¬[4-(2-pyrrolidin-l-ylethyl)piperazin-1-yl]urea,
•    N-[4-(5-cyclohexy1-2-methoxypheny1)-5-fluorothiazol¬20 2-yl]-W-[4-(1-methylpiperidin-4-yl)piperazin-1-y1]- urea,
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]urea,
•    N-[4-(5-cyclohexy1-2-ethoxyphenyl)thiazol-2-y1]-W¬25 [4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]urea,
•    N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]-N'- [4-(2-oxo-2-morpholino-4-ylethyl)piperazin-1-yl]urea,
•    N-[4-(5-cyclohexy1-2-ethoxyphenyl)thiazol-2-y1]-N'- 4-(2-oxo-2-morpholino-4-ylethyl)piperazin-1-yl]urea,
30 • (S) N-[4-(5-cyclohexy1-2-methoxyphenyl)thiazol-2-y1]- N'-[4-(1-sulphomethylpiperidin-3-ylmethyl)piperazin-1- yl]urea,
•    N-[4-(5-cyclohexyl-2-methoxyphenyl)thiazol-2-yl]-N'-
 
WO 2006/016039    97    PC7/FR2005/001729
[4-(1-oxo-1-(1-oz.00yridLn-2-y1)mell-1-1-ylpiperidin-3-y1-methy1piperazLr.-1-y1]ura.
6.    ?racess for preparing a compound of formuia (I)
5 according to any one of Claims 1 7.c. 5, comprising the step con =stint in reaming a comnolind of formula (II)
w    itn an amine derivazive of formula (=II)
OM
in which EkLf R2, 1, R end a arc as defLned iE Claim
0 and Rf represents a plfecurscr group oi R3 or a group R3 as definzld in C1.7.im 1, dn the preaence cf a coupling agent and in a solvent such as dichlorcmcthanc, dimethy_fcrmamlde or tolupnft, ir the presence of a ba:Lie such Zs tziethylarLne or K2CO3, at a temperatIre ranging
15 frcm Gc.0 Lo 100'C.
7    Compound of formula (1I.a) belcw:
 
In which:
R1 represents a ba.Dgen a7o7r., nr an -0- (CI-CO alkyl
m    /    (c3-1..:10) .-7-y...:1alkyl(Ci-C.) alkyl group;
-    R2 represents an -0-(Ci-Co)alkyl,    (Ca-',:a)a=kyl,
indexation.Ist QCOK tags.Ist

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