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(11)    Patent No :    AP 1919   
(21)    Application No :    AP/P/2004/003045   
(22)    Filing Date :    20.11.2002   
(24)    Date of Grant &    13.11.2008   
(45)    Publication :

(30)  Priority Data           
(33) Country    (31)    Number    (32) Date
JP    2001    -356018    21.11.2001

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW

(73) Applicant(s)

EISAI R&D MANAGEMENT CO., LTD, 4- 6-10 Koishikawa,

Bunkyo-ku, Tokyo 112-8088,

(72) Inventors

AOKI Shigeru, Japan

(74) Representative


(51)  International  Classification   A61K 9/22 (2006.01)    A61K 9/28 (2006.01)
A61K 31/4439 (2006.01)   

(54)    Title

Preparation compositions containing acid-unstable physiologically active compounds and process for producing the same

(57)    Abstract

It is intended to disclose preparation compositions which enable convenient production of sustained-release preparation compositions containing
acid-unstable physiologically active compounds and have the desired sustained-release properties. Namely, preparation compositions comprising a core containing an acid-unstable physiologically active compound and a film with which the core is coated and which contains a mixture of a water-insoluble polymer with an enteric polymer. These preparation compositions make it possible to maintain an effective concentration in blood of the physiologically active compound over a long time, thereby improving its

therapeutic effect. Moreover, the compositions according to the present

(56)  Documents Cited :    EP 1 123 700 A


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