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(11)    Patent No :      AP 1918   

(73) Applicant(s)       
(21)    Application No :    AP/P/2004/003034    PFIZER PRODUCTS INC., Eastern Point Road, Groton,       
            Connecticut 06340,       
(22)    Filing Date :            08.11.2002    United States of America       
(24)    Date of Grant &            AMGEN FREMONT INC., 6701 Kaiser Drive, Fremont,       
        13.11.2008    California 94555,       
(45)    Publication :                United States of America       
(30)    Priority Data                    (72) Inventors       
    (33) Country    (31) Number    (32) Date    BEDIAN Vahe, United States of America       
    US    60/348,980        09.11.2001    GLADUE Ronald Paul, United States of America       
                        CORVALAN Jose, United States of America       
                        et al           
                        (74) Representative       
(84)    Designated State                   
    GM  GH   KE    LS   MW    MZ    SL   SD   SZ    FISHER CORMACK & BOTHA       
    T Z   UG   ZM   ZW                       
(51)    International    Classification    A01H 5/00 (2006.01)    A01K 67/027 (2006.01)       
                    A61K 31/7088 (2006.01)           

(54)    Title

Antibodies to CD40

(57)    Abstract

The present invention relates to antibodies and antigen -binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light

immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid

(56)  Documents Cited :    US 6 312 693 A


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