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(11)    Patent No :    AP 2717   
(21)    Application No :    AP/P/2009/005039   
(22)    Filing Date :    13.05.2008   
(24)    Date of Grant &    31.07.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    07108176.4    14.05.2007
US    60/917,821    14.05.2007


(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW
(73) Applicant(s)
JANSSEN PHARMACEUTICA NV, Turnhoutseweg 30,

B-2340
Belgium
(72) Inventors

DICKENS Julius W. J., Belgium

HOUPIS Ioannes, Nicolas, Belgium

LANG Yolande Lydia, Belgium
et al

(74) Representative

HONEY & BLANCKENBERG
(51)  International  Classification   C07D 211/26 (2006.01)    C07D 401/14 (2006.01)
A61K 31/506 (2006.01)    A61P 35/00 (2006.01)
(54)    Title

Mono-hydrochloric salts of an inhibitor of histone deacetylase

(57)    Abstract

This invention provides novel crystalline forms of mono -HCl salts and a mono-HCl salt hydrate of JNJ-26481585, an inhibitor of histone deacetylases. The invention also relates to processes for production of these forms, to intermediates used in these processes, to pharmaceutical compositions comprising these forms, and to the use of these forms in medical treatment for instance as a medicine to inhibit proliferative conditions, such as cancer and leukemia

(56)    Documents Cited :    WO 2006/010750 A

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