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(11)    Patent No :    AP 1895   

(73) Applicant(s)    PFIZER PRODUCTS INC., Eastern Point Road, Groton,       
            Connecticut 06340,   
(21)    Application No :    AP/P/2002/002529           
                   
(22)    Filing Date :    10.11.2000    United States of America       
(24)    Date of Grant &    08.10.2008           
                   
(45)    Publication :

(30)  Priority Data    (72) Inventors

    (33) Country    (31) Number    (32) Date    BARTH WAyne, Ernest, United States of America   
    US            60/168,217    30.11.1999    LUZZIO Michael Joseph, United States of America   
                           
                        LYSSIKATOS Joseph Peter, United States of   
                        America       
                        et al       
                        (74) Representative   
(84)    Designated State           
                   
    GM    GH    KE    LS   MW  MZ    SL   SD   SZ    GALLOWAY & COMPANY   
    T Z    UG    ZW                   
                   
(51)    International    Classification    A61K 31/4709 (2006.01)    C07D491/056 (2006.01)   
                    A61K 31/47 (2006.01)       


(54)    Title

Novel benzoimidazole derivatives useful as antiproliferative agents.

(57)    Abstract

The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1,R7,R8,R9,R10, and R11 are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

(56)    Documents Cited :    WO 99 16755 A   WO 92 20642 A   J. MED. CHEM. 1998, 41, 5157-65    J. MED. CHEM.

1999,

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