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(11) Patent No : AP 1895
(73) Applicant(s) PFIZER PRODUCTS INC., Eastern Point Road, Groton,
(21) Application No : AP/P/2002/002529
(22) Filing Date : 10.11.2000 United States of America
(24) Date of Grant & 08.10.2008
(45) Publication :
(30) Priority Data (72) Inventors
(33) Country (31) Number (32) Date BARTH WAyne, Ernest, United States of America
US 60/168,217 30.11.1999 LUZZIO Michael Joseph, United States of America
LYSSIKATOS Joseph Peter, United States of
(84) Designated State
GM GH KE LS MW MZ SL SD SZ GALLOWAY & COMPANY
T Z UG ZW
(51) International Classification A61K 31/4709 (2006.01) C07D491/056 (2006.01)
A61K 31/47 (2006.01)
Novel benzoimidazole derivatives useful as antiproliferative agents.
The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1,R7,R8,R9,R10, and R11 are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
(56) Documents Cited : WO 99 16755 A WO 92 20642 A J. MED. CHEM. 1998, 41, 5157-65 J. MED. CHEM.