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(11)    Patent No :    AP 2670   
(21)    Application No :    AP/P/2009/004871   
(22)    Filing Date :    04.12.2007   
(24)    Date of Grant &    15.05.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
EP    06125510.5    06.12.2006

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)

JANSSEN PHARMACEUTICA N.V., Turnhoutseweg 30,

B-2340, Beerse,
Belgium
(72) Inventors
GUILLEMONT Jérôme Emile Georges, France
DORANGE Ismet, Sweden
MOTTE Magali Madeleine Simone, France
et al
(74) Representative
HONEY & BLANCKENBERG
(51)    International  Classification   C07D 215/22 (2006.01)    C07D 401/06 (2006.01)
    C07D 401/10 (2006.01)    C07D 405/06 (2006.01)
    C07D 405/10 (2006.01)    C07D 409/10 (2006.01)
    A61K 31/435    (2006.01)    A61P 31/00 (2006.01)
(54)    Title       
    Antibacterial quinoline derivatives       

(57)    Abstract

The present invention relates to novel substituted quinoline derivatives according to the general Formula (la) or Formula (lb): including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.

(56)    Documents Cited :    WO 2005/117875 A    WO 2006/067048 A    WO 2004/011436 A

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