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(11)    Patent No :    AP 2666   
(21)    Application No :    AP/P/2007/003873   
(22)    Filing Date :    01.07.2005   
(24)    Date of Grant &    17.05.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/586,839    09.07.2004

(84)    Designated State
BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
(73) Applicant(s)
GILEAD SCIENCES, INC., 333 Lakeside Drive, Foster City,

CA 94404,
United States of America
(72) Inventors

DAHL Terrence C, United States of America

(74) Representative

HONEY & BLANCKENBERG
(51)  International  Classification   A61K 31/00 (2006.01)    A61K 9/12 (2006.01)
A61K 9/48 (2006.01)    A61K 9/16 (2006.01)
A61K 9/06 (2006.01)   

(54)    Title

Topical antiviral formulations

(57)    Abstract

The present invention relates to formulations of nuclcotidc reverse transcriptase inhibitors (NRTIs), preferably
[2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid (tenofovir, PMPA), or a physiologically functional derivative thereof, suitable for topical application and their use in the prevention of HIV infections.

(56)  Documents Cited :    EP 1 243 590 A    CUNDY K C et al    TURPIN J A    VAN ROMPAY KOEN K et al    KARARLI
    TUGRIL T et al    WO 00/16755 A    PAUWELS RUDI ET AL

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