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(11)    Patent No :    AP 2621   
(21)    Application No :    AP/P/2007/004276   
(22)    Filing Date :    16.06.2006   
(24)    Date of Grant &    19.03.2013   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60/691,391    17.06.2005
US    11/452,545    14.06.2006


(84)    Designated State

BW    GM  GH   KE   LS   MW  MZ   NA   SL

SD    SZ   T Z   UG   ZM   ZW
 

(73) Applicant(s)

ENDORECHERCHE, INC., 2989 de la Promenade, Sainte-Foy, Quebec G1W 2J5,
Canada
72) Inventors
LABRIE Fernand, Canada
BRETON Rock, Canada
SINGH Shankar Mohan, Canada
et al
(74) Representative
HONEY & BLANCKENBERG

(51)  International  Classification   C07D 233/42 (2006.01)    A61K 31/4178 (2006.01)
A61K 31/4166 (2006.01)    A61K 31/5377(2006.01)
C07D 403/12 (2006.01)    C07D 413/12 (2006.01)

(54)    Title

Helix 12 directed non-steroidal antiandrogens

(57)    Abstract

Compounds having the structure or their salts are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer,

benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with

(56)    Documents Cited :    WO 00/37430    CA 2 526 540    US 5556983

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