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(11)    Patent No :    AP 1880   
(21)    Application No :    AP/P/2002/002711   
(22)    Filing Date :    06.06.2001   
(24)    Date of Grant &    19.08.2008   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
FR    00/07231    06.06.2000
(84)    Designated State

G    GH    KE   LS   MW  MZ   SL   SD   SZ
T Z    UG    ZW
 
(73) Applicant(s)

SCR PHARMATOP, Résidence Concorde, 10 square Saint-Florentin, Le Chesnay F-78150,
France

(72) Inventors

DIETLIN Francois, France

FREDJ Daniéle, France

(74) Representative

FISHER CORMACK & BOTHA

(51)  International  Classification   A61K    9/08 (2006.01)    A61K 31/136 (2006.01)
A61K    31/05 (2006.01)   

(54)    Title

Method for obtaining aqueous formulations of oxidation sensitive active principles.

(57)    Abstract

The invention concerns the field of organic chemistry and more particularly that of therapeutic chemistry. More precisely, it concerns a method for obtaining aqueous formulations of easily oxidizable active principles, in particular phenols, stable over a prolonged period, which consists in advanced

bubbling deoxygenation with an inert gas and/or vacuumizing them, while protecting them against possible oxygen uptake by maintaining them under inert gas atmosphere, by filling under inert gas into bottles previously made air-free by inert gas blowing, then in subjecting them when they are being closed to a vacuum so as to obtain in the bottle a pressure of not more than 65.000 Pa, thereby obtaining solutes having a residual oxygen concentration in the solution, less than 2 ppm, and preferably of the order of 1 ppm and even 0.5 ppm. The invention is useful in particular for preparing injection

(56)    Documents Cited :    WO 94 08602 A    WO 94 13274 A    WO 01/93830 A    WO 98 05314 A    FR 2 740 338 A

EP

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