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Back to the List of the Granted Patents                                                Click here to download AP2528 PDF

(11)Patent No :AP 2528

(21)Application No :AP/P/2006/003748

(22)Filing Date :31.03.2005

(24)Date of Grant &10.12.2012

 

(45)Publication : 

 

(30)  Priority Data

(33) Country(31) Number(32) Date

EP04101336.831.03.2004

(84)Designated State 

 

BWGMGHKELSMW  MZ   NA   SL

SDSZT ZUGZMZW

(73) Applicant(s)

 

TIBOTEC PHARMACEUTICALS LTD., Little Island , Co Cork,

 

Ireland

(72) Inventors

 

QUAEDFLIEG Peter Jan Leonard Mario, The

 

Netherlands

 

KESTELEYN Bart Rudolf Romanie, Belgium

 

VIJN Robert Jan, The Netherlands

 

et al

 

(74) Representative

 

HONEY & BLANCKENBERG

 

(51)  International  Classification   C07D493/04 (2006.01)C07D 307/20 (2006.01)

C07H15/04 (2006.01)

 

(54)Title 

 

Methods for the preparation of (3R,3aS,6aR) hexahydro- furo [2,3-b] furan-3-ol 

 

(57)Abstract 

 

The present invention relates to methods for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol (6) as well as a novel intermediate, (3aR,4S,6aS) 

 

4-methoxy-tetrahy-dro-furo[3,4-b]furan-2-one (4) for use in said methods. More in particular the invention relates to a stereosclectivc method for the preparation of diastereomerically pure (3R,3aS,6aR) 

 

hexahydro -furo[2,3-b]furan-3-ol, as well crystallization of (3aR,4S,6aS) 

 

4-methoxy-tetrahydro -furo[3,4-b]furan- 2-one and for the epimerization of (3aR,4R,6aS) 4-methoxy-tetrahy-dro-furo[3,4-b]-furan-2-one to (3aR,4S,6aS) 4-methoxy-tetrahydro7furo[3,4 -b]furan-2-one 

 

(56)Documents Cited :WO 03/022853 A    GHOSH et al

 

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