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(11)    Patent No :    AP 2507   
(21)    Application No :    AP/P/2006/003694   
(22)    Filing Date :    21.01.2005   
(24)    Date of Grant &    16.11.2012   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
US    60-538,907    23.01.2004

(84)    Designated State

BW    GM    GH    KE    LS    MW  MZ   NA   SL
SD    SZ    T Z    UG    ZM    ZW
 

(73) Applicant(s)

JANSSEN PHARMACEUTICA N.V., Turnhoutseweg 30,

B-2340 Beerse,
Belgium

(72) Inventors

GUILLEMONT Jerome Emile Georges, France

PASQUIER Elisabeth Therese Jeanne, France

LANCOIS David Francis Alain, France

et al

(74) Representative

HONEY & BLANCKENBERG
 

(51)  International  Classification   C07D 215/38 (2006.01)    C07D 215/14 (2006.01)
C07D 215/227 (2006.01)    C07D 401/04 (2006.01)
C07D 401/12 (2006.01)    C07D 401/14 (2006.01)
C07D 405/04 (2006.01)    C07D 405/06 (2006.01)
C07D 405/12 (2006.01)    C07D 405/14 (2006.01)
C07D 409/04 (2006.01)    C07D 409/14 (2006.01)

(54)    Title

Quinoline derivatives and use thereof as mycobacterial inhibitors

(57)    Abstract

The present invention relates to novel substituted quinoline derivatives according to the general Formula (la) or the general Formula (lb) the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases

(56)    Documents Cited :    WO 2004/011436 A    WOMMACK J B et al    US 5 965 572 A    WO 02/056882 A    WO

2004/002490 A

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