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(11)    Patent No :    AP 2174   
(21)    Application No :    AP/P/2006/003580   
(22)    Filing Date :    28.09.2004   
(24)    Date of Grant &    20.11.2010   
           
(45)    Publication :

(30)  Priority Data       
(33) Country    (31) Number    (32) Date
GB    0323236.0    03.10.2003
GB    0325020.6    27.10.2003
GB    0418566.6    19.08.2004

et al

(84)    Designated State

GM    GH   KE   LS   MW  MZ   SL   SD   SZ

T Z   UG   ZW
 
(73) Applicant(s)

PFIZER INC., 235 East 42nd Street , New York, New York 10017,
United States of America

(72) Inventors

STUPPLE Paul Anthony, United Kingdom


(74) Representative

GALLOWAY & COMPANY

ZIMBABWE
 

(51)  International  Classification   A61K 31/4745 (2006.01)    A61P 31/18 (2006.01)
C07D 471/02 (2006.01)   


(54)    Title

Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflamation.

(57)    Abstract

The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HTV and genetically

related retroviruses.

(56)    Documents Cited :    WO 03/084954 A    WO 01/90106 A    WO 00/38680 A