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(11) Patent No : AP 2174
(21) Application No : AP/P/2006/003580
(22) Filing Date : 28.09.2004
(24) Date of Grant & 20.11.2010
(45) Publication :
(30) Priority Data
(33) Country (31) Number (32) Date
GB 0323236.0 03.10.2003
GB 0325020.6 27.10.2003
GB 0418566.6 19.08.2004
et al
(84) Designated State
GM GH KE LS MW MZ SL SD SZ
T Z UG ZW
(73) Applicant(s)
PFIZER INC., 235 East 42nd Street , New York, New York 10017,
United States of America
(72) Inventors
STUPPLE Paul Anthony, United Kingdom
(74) Representative
GALLOWAY & COMPANY
ZIMBABWE
(51) International Classification A61K 31/4745 (2006.01) A61P 31/18 (2006.01)
C07D 471/02 (2006.01)
(54) Title
Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflamation.
(57) Abstract
The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HTV and genetically
related retroviruses.
(56) Documents Cited : WO 03/084954 A WO 01/90106 A WO 00/38680 A